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Mivotilate - 99%, high purity , CAS No.130112-42-4

COA

Grade & Purity:

≥99%

Cas Number: 130112-42-4
Molecular Weight: 330.45
PubChem CID: 148185

In stock

Item Number

M649583

Grouped product items
SKU	Size	Availability	Price
M649583-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
M649583-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
M649583-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90
M649583-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,450.90

View related series

Aryl Hydrocarbon Receptor (60) Immunology/Inflammation (1929)

Basic Description

Synonyms	CCRIS 8469 \| isopropyl-2-(1,3-dithietane-2-ylidene)-2-[n-(4-methylthiazol-2-yl)carbamoyl]acetate \| Q27236278 \| Propanedioic acid, (dimercaptomethylene)-, bis(1-methylethyl) ester \| Isopropyl-2-(1,3-dithietane-2-ylidene)-2-(N-(4-methylthiazol-2-yl)carbamoy
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR) , and acts as a hepatoprotective agent.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR) , and acts as a hepatoprotective agent. In Vitro Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal administration Male outbred Sprague-Dawley rats (weighing 100-150 g) are kept on a 12-h light-dark cycle with NIH 31 autoclavable rat die and water ad libitum. After a single oral administration of Mivotilate (75, 150, and 300 mg/kg body wt, diluted in corn oil) , the animals are sacrificed at different times as indicated. Livers from control (corn oil-treated) , starved (2 days) and Mivotilate -treated animals (n = 5 per group) are immediately excised, freeze-clamped, and processed further. Another group of rats (n = 3) is treated with phenobarbital (100 mg/kg/day) by intraperitoneal injection for 2 days and sacrificed 24 h after the last dose . aladdin has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Aryl hydrocarbon receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass N-arylamides

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	N-arylamides
Intermediate Tree Nodes	Not available
Direct Parent	N-arylamides
Alternative Parents	2,4-disubstituted thiazoles Vinylogous thioesters Heteroaromatic compounds Enoate esters Secondary carboxylic acid amides Ketene acetals Dithietanes Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	N-arylamide - 2,4-disubstituted 1,3-thiazole - Vinylogous thioester - Azole - Thiazole - Heteroaromatic compound - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Carboxamide group - Carboxylic acid ester - Dithietane - Ketene acetal or derivatives - Secondary carboxylic acid amide - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Organooxygen compound - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as n-arylamides. These are organic compounds that contain a carboxamide group that is N-linked to a aryl group. They have the generic structure RC(=O)N(R')H, R = organyl group and R'= aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	propan-2-yl 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-1,3-thiazol-2-yl)amino]-3-oxopropanoate
INCHI	InChI=1S/C12H14N2O3S3/c1-6(2)17-10(16)8(11-19-5-20-11)9(15)14-12-13-7(3)4-18-12/h4,6H,5H2,1-3H3,(H,13,14,15)
InChIKey	WOUUWUGULFOVHG-UHFFFAOYSA-N
Smiles	CC1=CSC(=N1)NC(=O)C(=C2SCS2)C(=O)OC(C)C
Isomeric SMILES	CC1=CSC(=N1)NC(=O)C(=C2SCS2)C(=O)OC(C)C
WGK Germany	3
PubChem CID	148185
Molecular Weight	330.45

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 12.5 mg/mL (37.83 mM; ultrasonic and warming and heat to 60°C)
Molecular Weight	330.500 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	330.017 Da
Monoisotopic Mass	330.017 Da
Topological Polar Surface Area	147.000 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	434.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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