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Miclxin - 99%, high purity , CAS No.2494198-61-5

COA

Grade & Purity:

≥99%

Cas Number: 2494198-61-5
Molecular Weight: 441.52
PubChem CID: 155891739

In stock

Item Number

M647362

Grouped product items
SKU	Size	Availability	Price
M647362-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
M647362-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$490.90
M647362-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,050.90

View related series

Stem Cell/Wnt (1019) β-catenin (56)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targ
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60 , a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex. In Vitro Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin-mutated HCT116 cells and isogenic HCT116 (CTNNB1 Δ45/-) cells, and induces (10 μM; 24 h) apoptosis in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–) Concentration: 0, 5, 8, 10, 12, and 15 μM Incubation Time: 48 hours Result: Inhibited cell growth with inhibition rate of 100% at 15 μM. Form:Solid

Names and Identifiers

IUPAC Name	7-methoxy-N-[(3-methoxyphenyl)methyl]-2-(3-pyridin-3-ylpyrrolidin-1-yl)quinazolin-4-amine
INCHI	InChI=1S/C26H27N5O2/c1-32-21-7-3-5-18(13-21)15-28-25-23-9-8-22(33-2)14-24(23)29-26(30-25)31-12-10-20(17-31)19-6-4-11-27-16-19/h3-9,11,13-14,16,20H,10,12,15,17H2,1-2H3,(H,28,29,30)
InChIKey	OXSWPFXQCLRTCF-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1)C(=NC(=N2)N3CCC(C3)C4=CN=CC=C4)NCC5=CC(=CC=C5)OC
PubChem CID	155891739
Molecular Weight	441.52

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