Skip to the beginning of the images gallery

Methyltetrazine-NHS ester - ≥95%, high purity , CAS No.1644644-96-1

COA

Grade & Purity:

≥95%

Cas Number: 1644644-96-1
Molecular Weight: 327.29
MDL number: MFCD28334557
PubChem CID: 86580472

In stock

Item Number

M463376

Grouped product items
SKU	Size	Availability	Price
M463376-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
M463376-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$259.90
M463376-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$649.90

View related series

Branched PEG (402) Conjugation chemistry (47) Lipid PEG (395) PEG NHS ester (198) PROTAC (2077) PROTAC Linkers (1898) Tetrazine-PEG (145) Tetrazines (1)

Basic Description

Synonyms	1-[2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetoxy]-2,5-pyrrolidinedione \| 2,5-Dioxopyrrolidin-1-yl 2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate \| N-Succinimidyl 2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate \| BD00822488
Specifications & Purity	≥95%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Description Methyltetrazine-NHS ester has anN-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive totrans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Tetrazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Tetrazines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Tetrazines
Alternative Parents	Pyrrolidine-2-ones Benzene and substituted derivatives Heteroaromatic compounds Dicarboximides Lactams Monocarboxylic acids and derivatives Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Monocyclic benzene moiety - Pyrrolidone - 2-pyrrolidone - Tetrazine - Benzenoid - Dicarboximide - Pyrrolidine - Heteroaromatic compound - Lactam - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Azacycle - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as tetrazines. These are organic compounds containing a tetrazine ring, which is a six-membered aromatic heterocycle made up of four nitrogen atoms and a two carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate
INCHI	InChI=1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3
InChIKey	BIHJLZOOHNOUCG-UHFFFAOYSA-N
Smiles	CC1=NN=C(N=N1)C2=CC=C(C=C2)CC(=O)ON3C(=O)CCC3=O
Isomeric SMILES	CC1=NN=C(N=N1)C2=CC=C(C=C2)CC(=O)ON3C(=O)CCC3=O
Molecular Weight	327.29
Reaxy-Rn	28080068
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28080068&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
A2503655	Certificate of Analysis	Dec 23, 2024	M463376
A2503660	Certificate of Analysis	Dec 23, 2024	M463376
A2503668	Certificate of Analysis	Dec 23, 2024	M463376
A2503669	Certificate of Analysis	Dec 23, 2024	M463376
A2503670	Certificate of Analysis	Dec 23, 2024	M463376
A2503671	Certificate of Analysis	Dec 23, 2024	M463376

Chemical and Physical Properties

Sensitivity	Light, Moisture and Heat sensitive
Flash Point(°F)	Not applicable
Flash Point(°C)	Not applicable
Molecular Weight	327.290 g/mol
XLogP3	-0.400
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	327.097 Da
Monoisotopic Mass	327.097 Da
Topological Polar Surface Area	115.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	482.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration