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Methapyrilene HCl , Histamine H1 receptor antagonist, CAS No.135-23-9, Histamine H1 receptor antagonist

COA COA
  • Cas Number:  135-23-9
  • Molecular Weight:  297.85
  • PubChem CID: 8667
In stock
Item Number
M333078
Grouped product items
SKU Size
Availability
 Price Qty
M333078-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$15.90
M333078-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
M333078-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
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a specialty product for proteomics research

View related series
Class A GPCR (4138) GPCR/G Protein (3172) Histamine Receptor (191) Immunology/Inflammation (1929) Neuronal Signaling (3320)

Basic Description

Synonyms 2-((2-(Dimethylamino)ethyl)-2-thenyl-amino)pyridine hydrochloride | CAS-135-23-9 | EU-0100851 | Blue Line | DTXSID0020818 | METHAPYRILENE HYDROCHLORIDE [WHO-DD] | SY284649 | W-53 hydrochloride | 00S42N58OM | CCG-39524 | Coryzol | MFCD00050665 | METHAPYRIL
Specifications & Purity Moligand™, ≥98%
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ANTAGONIST
Mechanism of action Histamine H1 receptor antagonist
Product Description

Methapyrilene HCl  is an H1-receptor antihistamine that is known to cause periportal hepatic necrosis following acute high dose administration to the rat subjects in in vitro studies carried out for the identification of mutagens and/or carcinogens.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Amines
Intermediate Tree Nodes Tertiary amines - Tertiary alkylarylamines
Direct Parent Dialkylarylamines
Alternative Parents Aminopyridines and derivatives  Imidolactams  Thiophenes  Heteroaromatic compounds  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Dialkylarylamine - Aminopyridine - Imidolactam - Pyridine - Heteroaromatic compound - Thiophene - Tertiary aliphatic amine - Azacycle - Organoheterocyclic compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
External Descriptors hydrochloride

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine;hydrochloride
INCHI InChI=1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;/h3-8,11H,9-10,12H2,1-2H3;1H
InChIKey BONORRGKLJBGRV-UHFFFAOYSA-N
Smiles CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2.Cl
Isomeric SMILES CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2.Cl
UN Number 2811
Packing Group I
Molecular Weight 297.85
Reaxy-Rn 6099172
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6099172&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity light sensitive；Hygroscopic
Molecular Weight 297.800 g/mol
XLogP3
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 6
Exact Mass 297.107 Da
Monoisotopic Mass 297.107 Da
Topological Polar Surface Area 47.600 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 235.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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