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Mesendogen - 99%, high purity , CAS No.864716-85-8

COA

Grade & Purity:

≥99%

Cas Number: 864716-85-8
Molecular Weight: 400.85
PubChem CID: 2173015

In stock

Item Number

M648787

Grouped product items
SKU	Size	Availability	Price
M648787-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$105.90
M648787-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
M648787-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90
M648787-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90
M648787-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,150.90

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium h
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development. In Vitro Mesendogen (10 μM) induces hESC mesoderm and endoderm differentiation, and decreases the level of neural differentiation markers. Mesendogen (2.5, 10 and 25 μM; overnight) dose-dependently reduces intracellular magnesium level in H1 hESCs. Mesendogen (10 μM; 7 days) inhibits the neural differentiation activity induced by Dorsomorphin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: H9 hESCs Concentration: 10 μM Incubation Time: 7 days Result: Downregulated expression levels of pluripotency markers OCT4 and SOX2. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass N-phenylthioureas

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	N-phenylthioureas
Intermediate Tree Nodes	Not available
Direct Parent	N-acyl-phenylthioureas
Alternative Parents	Trifluoromethylbenzenes Aromatic monoterpenoids Monocyclic monoterpenoids Phenylpropanes Benzoic acids and derivatives Cumenes Benzoyl derivatives Chlorobenzenes Aryl chlorides Thioureas Carboxylic acids and derivatives Organochlorides Organic oxides Organonitrogen compounds Hydrocarbon derivatives Organooxygen compounds Alkyl fluorides Organopnictogen compounds Organofluorides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	N-acyl-phenylthiourea - P-cymene - Aromatic monoterpenoid - Monocyclic monoterpenoid - Trifluoromethylbenzene - Monoterpenoid - Benzoic acid or derivatives - Cumene - Phenylpropane - Benzoyl - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Thiourea - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organofluoride - Alkyl halide - Organonitrogen compound - Organooxygen compound - Alkyl fluoride - Organic oxygen compound - Organic nitrogen compound - Organosulfur compound - Organohalogen compound - Organochloride - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as n-acyl-phenylthioureas. These are thiourea derivatives where one nitrogen atom of the urea group is linked to a phenyl group and the other is acylated.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	N-[[2-chloro-5-(trifluoromethyl)phenyl]carbamothioyl]-4-propan-2-ylbenzamide
INCHI	InChI=1S/C18H16ClF3N2OS/c1-10(2)11-3-5-12(6-4-11)16(25)24-17(26)23-15-9-13(18(20,21)22)7-8-14(15)19/h3-10H,1-2H3,(H2,23,24,25,26)
InChIKey	VVFIVYCBLSSVEK-UHFFFAOYSA-N
Smiles	CC(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=C(C=CC(=C2)C(F)(F)F)Cl
Isomeric SMILES	CC(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=C(C=CC(=C2)C(F)(F)F)Cl
PubChem CID	2173015
Molecular Weight	400.85

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	400.800 g/mol
XLogP3	6.200
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	400.062 Da
Monoisotopic Mass	400.062 Da
Topological Polar Surface Area	73.200 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	507.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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