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Mepivacaine HCl - ≥98%, high purity , Sodium channel alpha subunit blocker, CAS No.1722-62-9, Sodium channel alpha subunit blocker
Basic Description
Synonyms
1-Methyl-2',6'-pipecoloxylidide monohydrochloride | MEPIVACAINE HYDROCHLORIDE [MI] | CCG-39081 | MEPIVACAINE HYDROCHLORIDE [USP MONOGRAPH] | Scandonest 3% Plain | Carbocaina | Carbocaine (TN) | HY-B0517A | M2560 | Mepivacaine Monohydrochloride | SMR000058
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Local anesthetic. Reversibly blocks inward current of transient Na+, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.
Shipped In
Normal
Action Type
BLOCKER
Mechanism of action
Sodium channel alpha subunit blocker
Product Description
Mepivacaine is a tertiary amine used as a local anesthetic.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Piperidines
Subclass
Piperidinecarboxylic acids and derivatives
Intermediate Tree Nodes
Not available
Direct Parent
Piperidinecarboxamides
Alternative Parents
m-Xylenes Trialkylamines Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
2-piperidinecarboxamide - Piperidinecarboxamide - M-xylene - Xylene - Monocyclic benzene moiety - Benzenoid - Tertiary aliphatic amine - Tertiary amine - Carboximidic acid - Carboximidic acid derivative - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Amine - Hydrochloride - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as piperidinecarboxamides. These are compounds containing a piperidine ring substituted with a carboxamide functional group.
External Descriptors
hydrochloride - piperidinecarboxamide
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
Pubchem Sid
488183718
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/488183718
IUPAC Name
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide;hydrochloride
INCHI
InChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
InChIKey
RETIMRUQNCDCQB-UHFFFAOYSA-N
Smiles
CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl
Isomeric SMILES
CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl
WGK Germany
3
RTECS
TK6475000
Molecular Weight
282.81
Reaxy-Rn
3734352
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3734352&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Solubility
DMSO 3 mg/mL Water 57 mg/mL Ethanol 8 mg/mL
Melt Point(°C)
263oC
Molecular Weight
282.810 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
282.15 Da
Monoisotopic Mass
282.15 Da
Topological Polar Surface Area
32.299 Ų
Heavy Atom Count
19
Formal Charge
0
Complexity
282.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
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D2319918