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Memantine Hydrochloride - 98%, high purity , Glutamate [NMDA] receptor negative allosteric modulator, CAS No.41100-52-1, Glutamate [NMDA] receptor negative allosteric modulator

3 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
M107928
Grouped product items
SKU Size
Availability
 Price Qty
M107928-250mg
250mg
1
$9.90
M107928-1g
1g
10
$15.90
M107928-5g
5g
2
$27.90
M107928-25g
25g
2
$81.90
M107928-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$294.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

NMDA antagonist, ion channel site

View related series
Autophagy (1917) Ion channel (2197) Lipid metabolism (1912) Nitrogenous compounds (2445) Non heterocyclic block (8163)

Basic Description

Synonyms MEMANTINE HYDROCHLORIDE (USP-RS) | Memantine Accord | NMI-131 | 3,5-dimethyladamantan-1-amine;hydrochloride | Axura | EINECS 255-219-6 | NCGC00262963-01 | 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride | AMY40819 | SMR000875213 | MLS0013326
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Us
Shipped In Normal
Action Type NEGATIVE ALLOSTERIC MODULATOR
Mechanism of action Glutamate [NMDA] receptor negative allosteric modulator
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Memantine hydrochloride has been used:

· as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity

· to intraperitoneally inject experimental animal to study its effect on traumatic injury

· as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Amines
Intermediate Tree Nodes Primary amines
Direct Parent Monoalkylamines
Alternative Parents Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Primary aliphatic amine - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.
External Descriptors hydrochloride

Associated Targets(Human)

TRPV1 Tclin Vanilloid receptor (8273 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A 172 (535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-87 MG (3946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate NMDA receptor; GRIN1/GRIN2A (719 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2b (1028 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488188516
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488188516
IUPAC Name 3,5-dimethyladamantan-1-amine;hydrochloride
INCHI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey LDDHMLJTFXJGPI-UHFFFAOYSA-N
Smiles CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
Isomeric SMILES CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
WGK Germany 3
Molecular Weight 215.76
Reaxy-Rn 6573843
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6573843&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
I1502007 Certificate of Analysis May 06, 2023 M107928
J2214642 Certificate of Analysis Sep 27, 2022 M107928
D2318305 Certificate of Analysis Sep 27, 2022 M107928
J2214652 Certificate of Analysis Sep 27, 2022 M107928
J2214653 Certificate of Analysis Sep 27, 2022 M107928
D1828168 Certificate of Analysis Mar 24, 2022 M107928
D1828167 Certificate of Analysis Mar 24, 2022 M107928

Chemical and Physical Properties

Solubility Soluble in water
Melt Point(°C) 292°C
Molecular Weight 215.760 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 0
Exact Mass 215.144 Da
Monoisotopic Mass 215.144 Da
Topological Polar Surface Area 26.000 Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 240.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Alternative Products

  1. no_selection
    Memantine HCl, Glutamate [NMDA] receptor negative allosteric modulator
    • 10mM in DMSO

    Starting at $186.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489). 
2. Fangfang Shen, Dingqiang Lu, Xiuquan Ling, Xinxian Wang, Tongqi Liu, Tianhua Huang, Kefei He.  (2017)  Thermodynamic analysis and calculation of solubility of Memantine hydrochloride in ethanol plus (acetonitrile, water, ethyl acetate) binary solvent mixtures.  JOURNAL OF MOLECULAR LIQUIDS,  229  (58). 
3. Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Deng.  (2024)  SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (136767). 

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