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Mefuparib hydrochloride - 98%, high purity , CAS No.1449746-00-2

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Mefuparib hydrochloride - 98%, high purity , CAS No.1449746-00-2

10 Citations

COA

Grade & Purity:

≥98%

Cas Number: 1449746-00-2
Molecular Weight: 334.77
PubChem CID: 117734810

In stock

Item Number

M646255

Grouped product items
SKU	Size	Availability	Price
M646255-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$48.90
M646255-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$168.90
M646255-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$293.90
M646255-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$586.90

View related series

Apoptosis (4276) Cell Cycle/DNA Damage (2602) DNA Damage (697) Epigenetics (1496) Histone Modification (1379) PARP (124)

Basic Description

Synonyms	Mefuparib (hydrochloride) \| 82IYE3T3BE \| CVL-218 \| MPH \| hydrochloride \| 5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Mefuparib hydrochloride is a substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively. Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class 2-arylbenzofuran flavonoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	2-arylbenzofuran flavonoids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	2-arylbenzofuran flavonoids
Alternative Parents	2-phenylbenzofurans Phenylmethylamines Benzylamines Aralkylamines Aryl fluorides Heteroaromatic compounds Furans Oxacyclic compounds Dialkylamines Carboximidic acids Organopnictogen compounds Organooxygen compounds Organofluorides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	2-arylbenzofuran flavonoid - Phenylbenzofuran - 2-phenylbenzofuran - Benzofuran - Phenylmethylamine - Benzylamine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Heteroaromatic compound - Furan - Oxacycle - Organoheterocyclic compound - Secondary amine - Secondary aliphatic amine - Carboximidic acid derivative - Carboximidic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide;hydrochloride
INCHI	InChI=1S/C17H15FN2O2.ClH/c1-20-9-10-2-4-11(5-3-10)15-7-12-6-13(18)8-14(17(19)21)16(12)22-15;/h2-8,20H,9H2,1H3,(H2,19,21);1H
InChIKey	GPFWTAVHQKERKY-UHFFFAOYSA-N
Smiles	CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F.Cl
Isomeric SMILES	CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F.Cl
Alternate CAS	1449746-00-2
PubChem CID	117734810
MeSH Entry Terms	mefuparib hydrochloride;MPH1 cpd
Molecular Weight	334.77

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
E2431334	Certificate of Analysis	May 27, 2024	M646255
E2431343	Certificate of Analysis	May 27, 2024	M646255
E2431335	Certificate of Analysis	May 27, 2024	M646255

Chemical and Physical Properties

Solubility	DMSO : 25 mg/mL (74.68 mM; Need ultrasonic)
Sensitivity	Moisture sensitive.
Molecular Weight	334.800 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	334.088 Da
Monoisotopic Mass	334.088 Da
Topological Polar Surface Area	68.300 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	398.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shi-Hui Lu, Xiao-Na Liang, Xiao-Jin Nong, Ran Chen, Xiu-Xia Li. (2023) A New HPLC-UV Method Using Hydrolyzation with Sodium Hydroxide for Quantitation of Trans-p-Hydroxycinnamic Acid and Total Trans-p-Hydroxycinnamic Acid Esters in the Leaves of Ligustrum robustum. MOLECULES, 28 (14): (5309).
2. Cuichuan Zhang, Zhiqiang Lu, Bin Wu, Shu-Dong Jiang, Jiasheng Qian. (2023) Grafting of Maleic Anhydride onto Poly(vinylidene fluoride) Using Reactive Extrusion. MOLECULES, 28 (5): (2246).
3. Xiuying Liu, Qianna Xia, Jiao Zhou, Bowen Li, Shuaiqi Zhao, Long Chen, Aimal Khan, Xiaoxia Li, Aihua Xu. (2024) Morphology-dependent activation of hydrogen peroxide with Cu2O for tetracycline hydrochloride degradation in bicarbonate aqueous solution. Journal of Environmental Sciences, 137 (567).
4. Nan Xue, Yue Zhang, Chunyan Wang, Xueyan Xue, Dandan Ouyang, Hui Zhu, Jiao Yin. (2022) Enhancing oxygen reduction reaction performance in acidic media via bimetal Fe and Cr synergistic effects. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 47 (33979).
5. Nan Xue, Jing Liu, Pengyuan Wang, Chunyan Wang, Sen Li, Hui Zhu, Jiao Yin. (2020) Scalable synthesis of Fe3N nanoparticles within N-doped carbon frameworks as efficient electrocatalysts for oxygen reduction reaction. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 580 (460).
6. Yuchu He, Kang Niu, Liyao Luo, Lei Li, Cong Cong, Dawei Gao. (2019) Reduction and Protection: One-Step Synthesis of Polydopamine-Coated Silver Nanowires with Superior Biosafety for Cancer Treatment. ACS Sustainable Chemistry & Engineering, 7 (24): (20102–20106).
7. Xiao-Fang Song, Jiang-Tao Qin, Ting-Ting Li, Guo Liu, Xiang-Xiang Xia, Yue-Sheng Li, Yi Liu. (2019) Efficient construction and enriched selective adsorption-photocatalytic activity of PVA/PANI/TiO2 recyclable hydrogel by electron beam radiation. JOURNAL OF APPLIED POLYMER SCIENCE, 137 (13): (48516).
8. Yunxia Zhuang, Xiaodan Zhang, Qiumeng Chen, Siqi Li, Haiyan Cao, Yuming Huang. (2019) Co3O4/CuO hollow nanocage hybrids with high oxidase-like activity for biosensing of dopamine. Materials Science & Engineering C-Materials for Biological Applications, 94 (858).
9. Yunyan Wu, Yazhou Zhou, Han Xu, Qinqin Liu, Yi Li, Lili Zhang, Hanqing Liu, Zhigang Tu, Xiaonong Cheng, Juan Yang. (2018) Highly Active, Superstable, and Biocompatible Ag/Polydopamine/g-C3N4 Bactericidal Photocatalyst: Synthesis, Characterization, and Mechanism. ACS Sustainable Chemistry & Engineering, 6 (11): (14082–14094).
10. Lu-Lu Zhang,Wen Huang,Ying-Ying Zhang,Gang Fan,Jin He,Jing-Nan Ren,Zhi Li,Xiao Li,Si-Yi Pan. (2020-05-12) Genomic and Transcriptomic Study for Screening Genes Involved in the Limonene Biotransformation of Penicillium digitatum DSM 62840.. Frontiers in microbiology, 11 (744-744).

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