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Metabolic Enzyme/Protease
FBPase
MB05032 - 98%, high purity , CAS No.261365-11-1

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MB05032 - 98%, high purity , CAS No.261365-11-1

COA

Grade & Purity:

≥98%

Cas Number: 261365-11-1
Molecular Weight: 302.29
PubChem CID: 11289630

In stock

Item Number

M125090

Grouped product items
SKU	Size	Availability	Price
M125090-5mg	5mg	3	$309.90
M125090-10mg	10mg	2	$459.90
M125090-50mg	50mg	2	$1,229.90
M125090-100mg	100mg	1	$2,199.90

Potent FBPase inhibitor; promotes HSC expansion

View related series

FBPase (3) Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosphonic acid \| MB 05032 \| BDBM50293594 \| F84965 \| Geranylacetone, trans- \| XJMYIJPPDSZOPN-UHFFFAOYSA-N \| {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid \| P-(5-(2-Amino-5-(2-methylp
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent FBPase inhibitor (EC50values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhance
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Thiazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Thiazoles
Intermediate Tree Nodes	Not available
Direct Parent	2,4,5-trisubstituted thiazoles
Alternative Parents	2-amino-1,3-thiazoles Organic phosphonic acids Heteroaromatic compounds Furans Oxacyclic compounds Azacyclic compounds Primary amines Organophosphorus compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2,4,5-trisubstituted 1,3-thiazole - 1,3-thiazol-2-amine - Furan - Organophosphonic acid - Organophosphonic acid derivative - Heteroaromatic compound - Azacycle - Oxacycle - Organic oxygen compound - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2,4,5-trisubstituted thiazoles. These are compounds containing a thiazole ring substituted at positions 2, 4 and 5 only.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

FBP1 Tchem Fructose-1,6-bisphosphatase 1 (8 Activities)

Discover Target: FBP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FBP1 Tchem Fructose-1,6-bisphosphatase (1199 Activities)

Discover Target: FBP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
INCHI	InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
InChIKey	XJMYIJPPDSZOPN-UHFFFAOYSA-N
Smiles	CC(C)CC1=C(N=C(S1)N)C2=CC=C(O2)P(=O)(O)O
Isomeric SMILES	CC(C)CC1=C(N=C(S1)N)C2=CC=C(O2)P(=O)(O)O
Molecular Weight	302.29
Reaxy-Rn	11556280
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11556280&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
L2320039	Certificate of Analysis	Nov 29, 2023	M125090
L2320043	Certificate of Analysis	Nov 29, 2023	M125090
L2320056	Certificate of Analysis	Nov 29, 2023	M125090
L2320042	Certificate of Analysis	Nov 29, 2023	M125090
L2320044	Certificate of Analysis	Nov 29, 2023	M125090
L2320057	Certificate of Analysis	Nov 29, 2023	M125090
L2320064	Certificate of Analysis	Nov 29, 2023	M125090

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 30.23, Max Conc. mM: 100
Molecular Weight	302.290 g/mol
XLogP3	1.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	302.049 Da
Monoisotopic Mass	302.049 Da
Topological Polar Surface Area	138.000 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	365.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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