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Mangiferin - 95%, high purity , CAS No.4773-96-0
Basic Description
Synonyms
1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | DTXCID70119754 | UNII-1M84LD0UMD | AS-15337 | 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy- | NSC 248870 | Chinoinin | MANGIFERIN [USP-RS]
Specifications & Purity
≥95%
Biochemical and Physiological Mechanisms
Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic propert
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Product Description：
Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs.
Product Application：
Mangiferin has been used:
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Benzopyrans
Subclass
1-benzopyrans
Intermediate Tree Nodes
Dibenzopyrans - Xanthenes
Direct Parent
Xanthones
Alternative Parents
Phenolic glycosides Hexoses C-glycosyl compounds Chromones Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Oxanes Vinylogous acids Heteroaromatic compounds Secondary alcohols Polyols Oxacyclic compounds Dialkyl ethers Organic oxides Primary alcohols Hydrocarbon derivatives
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Phenolic glycoside - Xanthone - Hexose monosaccharide - C-glycosyl compound - Chromone - Glycosyl compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Benzenoid - Pyran - Oxane - Monosaccharide - Heteroaromatic compound - Vinylogous acid - Secondary alcohol - Oxacycle - Polyol - Dialkyl ether - Ether - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Organooxygen compound - Primary alcohol - Alcohol - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
External Descriptors
xanthenes
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
Pubchem Sid
504763370
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504763370
IUPAC Name
1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
INCHI
InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
InChIKey
AEDDIBAIWPIIBD-ZJKJAXBQSA-N
Smiles
C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O
Isomeric SMILES
C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
Molecular Weight
422.34
Reaxy-Rn
1359328
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359328&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Heat Sensitive
Melt Point(°C)
270 °C
Molecular Weight
422.300 g/mol
XLogP3
-0.400
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
11
Rotatable Bond Count
2
Exact Mass
422.085 Da
Monoisotopic Mass
422.085 Da
Topological Polar Surface Area
197.000 Ų
Heavy Atom Count
30
Formal Charge
0
Complexity
646.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
5
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Wanran Huang, Yanni Wang, Wei Huang.
(2023)
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. NEUROSCIENCE LETTERS,
(137608).
2.
Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu.
(2023)
Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense. ACS Chemical Neuroscience,
14
(8):
(1379–1387).
3.
Yuhang Xing, Ruyi Li, Lu Xue, Mianhong Chen, Xuli Lu, Zhihao Duan, Wei Zhou, Jihua Li.
(2022)
Double emulsion (W/O/W) gel stabilised by polyglycerol polyricinoleate and calcium caseinate as mangiferin carrier: insights on formulation and stability properties. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,
57
(8):
(5268-5279).
4.
Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang.
(2022)
A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing. JOURNAL OF CONTROLLED RELEASE,
341
(147).
5.
Yunbo Li, Benguo Liu, Mengmeng Yu, Sheng Geng.
(2021)
High-efficiency formation mechanism of mangiferin/γ-cyclodextrin complex. FOOD SCIENCE AND TECHNOLOGY RESEARCH,
6.
Chao Yin, Jun Zheng, Yufan Yang, Xianwen Song, Miao Cui, Rujuan Shen, Yi Zhang.
(2025)
A facile preparation strategy for multifunctional hydrogel films with adjustable performance in food preservation. Food Packaging and Shelf Life,
49
(101471).
7.
Mengke Hao, Simin Wei, Siqi Su, Zhishu Tang, Yinghui Wang.
(2024)
A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds. ACS Applied Materials & Interfaces,
16
(19):
(24221-24234).
8.
Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.
(2025)
An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds. FOOD CHEMISTRY,
(143873).
9.
Huilin Deng, Yaozhong Zheng, Qiongyao Wang, Jiaqi Peng, Weibin Bai, Lingmin Tian, Zouyan He, Rui Jiao.
(2025)
In vitro gastrointestinal digestion and colonic fermentation of Mangiferin: Impacts on gut microbiota and metabolite profiles. Journal of Functional Foods,
124
(106667).
10.
Cheng Lu, ShiJun Deng, YanJiao Liu, ShengJin Yang, DingMei Qin, LiJuan Zhang, Rui-rui Wang, Yi Zhang.
(2024)
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis. INTERNATIONAL IMMUNOPHARMACOLOGY,
133
(112038).
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10 Citations
H2429498