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Apoptosis
Apoptosis
LYG-202 - 92%, high purity , CAS No.1175077-25-4

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LYG-202 - 92%, high purity , CAS No.1175077-25-4

COA

Grade & Purity:

≥92%

Cas Number: 1175077-25-4
Molecular Weight: 438.52
PubChem CID: 44156930
PubChem SID: 504770290

In stock

Item Number

L345473

Grouped product items
SKU	Size	Availability	Price
L345473-1mg	1mg	3	$24.90
L345473-5mg	5mg	3	$95.90
L345473-10mg	10mg	3	$403.90
L345473-25mg	25mg	3	$908.90
L345473-50mg	50mg	2	$1,635.90

an inhibitor that induces apoptosis

View related series

Apoptosis (4276)

Basic Description

Synonyms	5-Hydroxy-8-methoxy-7-[4-(4-methyl-1-piperazinyl)butoxy]-2-phenyl-4H-1-benzopyran-4-one
Specifications & Purity	≥92%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	LYG-202 is an inhibitor of the proliferation of cancer cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21WAF1/Cip1 expression.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Flavonoids
    - Subclass O-methylated flavonoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Flavonoids
Subclass	O-methylated flavonoids
Intermediate Tree Nodes	Not available
Direct Parent	8-O-methylated flavonoids
Alternative Parents	5-hydroxyflavonoids Flavones Chromones Anisoles Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids N-methylpiperazines Alkyl aryl ethers Benzene and substituted derivatives Vinylogous acids Heteroaromatic compounds Trialkylamines Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	8-methoxyflavonoid-skeleton - 5-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - Anisole - Phenol ether - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - N-alkylpiperazine - N-methylpiperazine - Pyranone - Monocyclic benzene moiety - 1,4-diazinane - Benzenoid - Piperazine - Pyran - Vinylogous acid - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Organoheterocyclic compound - Azacycle - Ether - Oxacycle - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 8-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C8 atom of the flavonoid backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770290
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770290
IUPAC Name	5-hydroxy-8-methoxy-7-[4-(4-methylpiperazin-1-yl)butoxy]-2-phenylchromen-4-one
INCHI	InChI=1S/C25H30N2O5/c1-26-11-13-27(14-12-26)10-6-7-15-31-22-17-20(29)23-19(28)16-21(18-8-4-3-5-9-18)32-25(23)24(22)30-2/h3-5,8-9,16-17,29H,6-7,10-15H2,1-2H3
InChIKey	ICGYSEWPMDWBIL-UHFFFAOYSA-N
Smiles	CN1CCN(CC1)CCCCOC2=C(C3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=CC=C4)OC
Isomeric SMILES	CN1CCN(CC1)CCCCOC2=C(C3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=CC=C4)OC
Molecular Weight	438.52
Reaxy-Rn	21843054
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21843054&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
J2331478	Certificate of Analysis	Aug 10, 2023	L345473
J2331479	Certificate of Analysis	Aug 10, 2023	L345473
J2331480	Certificate of Analysis	Aug 10, 2023	L345473
J2331483	Certificate of Analysis	Aug 10, 2023	L345473
J2331484	Certificate of Analysis	Aug 10, 2023	L345473
J2331485	Certificate of Analysis	Aug 10, 2023	L345473
J2331481	Certificate of Analysis	Aug 10, 2023	L345473
J2331528	Certificate of Analysis	Aug 10, 2023	L345473
J2331486	Certificate of Analysis	Aug 10, 2023	L345473
J2331487	Certificate of Analysis	Aug 10, 2023	L345473

Chemical and Physical Properties

Molecular Weight	438.500 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	438.215 Da
Monoisotopic Mass	438.215 Da
Topological Polar Surface Area	71.500 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	642.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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