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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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L276596-1ml
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1ml |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$51.90
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PI3-kinase inhibitor
| Synonyms | SCHEMBL94377 | 31M2U1DVID | J-510126 | NCGC00015622-07 | s1105 | BiomolKI_000029 | DTXSID6042650 | EC-000.2341 | NCGC00015622-04 | NCI60_034712 | UNII-31M2U1DVID | 2-morpholino-8-phenyl-4H-chromen-4-one | 2-Morpholino-8-phenylchromone | CZQHHVNHHHRRDU-UHF |
|---|---|
| Specifications & Purity | Moligand™, ≥98%, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC 50 > 50 μM). Also available as a solid . |
| Storage Temp | Protected from light,Desiccated,Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kina |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Benzopyrans |
| Subclass | 1-benzopyrans |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Chromones |
| Alternative Parents | Dialkylarylamines Pyranones and derivatives Morpholines Benzene and substituted derivatives Vinylogous amides Heteroaromatic compounds Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Chromone - Dialkylarylamine - Pyranone - Monocyclic benzene moiety - Morpholine - Oxazinane - Pyran - Benzenoid - Vinylogous amide - Heteroaromatic compound - Ether - Dialkyl ether - Azacycle - Oxacycle - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as chromones. These are compounds containing a benzopyran-4-one moiety. |
| External Descriptors | organochlorine compound - morpholines - chromones |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | 2-morpholin-4-yl-8-phenylchromen-4-one |
|---|---|
| INCHI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| Smiles | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 |
| Isomeric SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 |
| Molecular Weight | 307.35 |
| Reaxy-Rn | 8156139 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8156139&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Aug 21, 2023 | L276596 |
| Solubility | Supplied in DMSO (10 mM) |
|---|---|
| Sensitivity | air and light sensitive |
| Melt Point(°C) | 184 °C |
| Molecular Weight | 307.300 g/mol |
| XLogP3 | 3.100 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 307.121 Da |
| Monoisotopic Mass | 307.121 Da |
| Topological Polar Surface Area | 38.800 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 463.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang. (2023) Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds. Frontiers in Pharmacology, 14 |
| 2. Na Li, Fanghan He, Yunxiao Shang. (2023) Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 119 (110149). |
| 3. Xuanhao Fu, Boyuan Ma, Mengmeng Zhou, Yuelin Cheng, Linyan Liu, Shunli Kan, Chengjiang Liu, Xinyan Zhao, Sa Feng, Haoqiang Zhu, Wei Hu, Zehua Jiang, Rusen Zhu. (2023) Network pharmacology integrated with experimental validation to explore the therapeutic role and potential mechanism of Epimedium for spinal cord injury. Frontiers in Molecular Neuroscience, 16 (1074703). |
| 4. Qin Yeyu, Xie Jing, Zheng Ruihe, Li Yuhang, Wang Haixia. (2022) Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity. Frontiers in Pharmacology, 13 |
| 5. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8): (2118-2126). |
| 6. Hu Gaowei, Miao Yingjie, Luo Xi, Chu Wenhui, Fu Yongqian. (2020) Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (24): (10503-10513). |
| 7. Chen Danping, Wang Yang, Mo Mingming, Zhang Junjie, Zhang Yanfei, Xu Yuzhi, Liu Si-Yang, Chen Jun, Ma Yingjun, Zhang Li, Dai Zong, Cai Chun, Zou Xiaoyong. (2019) Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input. NUCLEIC ACIDS RESEARCH, 47 (19): (e119-e119). |
| 8. Hu Gaowei, Zheng Wenlv, Li Ao, Mu Yaru, Shi Mingyu, Li Tuofan, Zou Haitao, Shao Hongxia, Qin Aijian, Ye Jianqiang. (2018) A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis. VETERINARY RESEARCH, 49 (1): (1-9). |
| 9. Xiaofei Li, Jian Li, Zhike Li, Ying Sang, Yunhui Niu, Qianying Zhang, Hong Ding, Shanye Yin. (2016) Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the L-NAME-induced hypertensive rat model. Food & Function, 7 (5): (2398-2408). |
| 10. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan. (2016) Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 100 (11): (5079-5088). |
| 11. Jing Zhao, Li Li, Ling Peng. (2015) MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway. International Journal of Clinical and Experimental Pathology, 8 (12): ( 15947–15953). |