Wearable biosensor with high specific surface area PGA-CNTs electrode for sweat glucose detection

Sweat glucose sensors have a high potential to detect blood glucose concentration conveniently and quickly, making them a focus of research on glucose detection methods. We prepare a polyglycolic acid-carbon nanotubes (PGA-CNTs) film with a high specific surface area, loaded with glucose oxidase (GOx) to develop a PGA-CNTs sweat glucose sensor. PGA films with a porous three-dimensional (3D) network structure were prepared by solvent evaporation, CNTs were deposited to obtain PGA-CNTs electrodes, and GOx was adsorbed through the high specific surface area structure of the 3D network. The results confirmed that the mesh structure formed by carbon nanotubes attached to PGA could substantially improve the charge transfer ability, and a considerable amount of GOx could be stably immobilized in the three-dimensional structure of the electrode. The PGA-CNTs sweat glucose sensor has excellent conductivity stability under bending and accurately detects glucose in the presence of other interference. The linear range of glucose response is 20–300 μM, and the sensitivity is 78.45 μA mM −1 cm −2 . Compared to existing products, the PGA-CNTs biosensors are more competitive in detection performance and cost.