Trimetallic ZIFs-derived nanoarchitecture for portable wireless electrochemical determination of chlorogenic acid in natural medicine and food samples

In this paper, a novel trimetallic zeolitic imidazolate frameworks (ZnCoMn-ZIFs) was successfully synthesized by a facile one-pot method at room temperature, which was further used to prepare a triatomic site anchored in N-doped carbon (Co 2 MnN 8 @C) hybrid nanostructure via a pyrolysis method. The synthesized Co 2 MnN 8 @C was modified on the screen-printed carbon electrode, and the modified electrode was used for the portable wireless sensitive determination of chlorogenic acid (CGA) by differential pulse voltammetry. The Co 2 MnN 8 @C exhibited large surface area and excellent catalytic activity with increasing Co and Mn sites, which could selectively combine with CGA to enhance the sensitivity of the electrochemical sensor. Under the optimized conditions, the constructed sensor had wider linear ranges for CGA analysis from 0.05–10.0 μmol/L and 10.0–100.0 μmol/L with a detection limit of 0.0075 μmol/L (3S 0 /S). The sensor was successfully applied to detect CGA in natural medicine and food samples with satisfied recoveries. Therefore, the proposed strategy may stimulate the exploration of trimetallic ZIFs with more active sites for the development of sensitive electrochemical sensors.