Stereoselective signal amplification for multiplex detection of tyrosinamide

The recognition and separation of stereoselective molecules with similar chemical properties and structures are of great biological significance. Developing a highly effective chiral recognition platform is crucial for further research on chiral molecules. Herein, a chiral aptamer-modified gold nanoclusters functionalized electrochemical device that exhibits an ideal platform for enantioselective recognition is reported. Its electrochemical current restriction amplification strategy enables stereoselective signal amplification on an electrode. It is found that introducing chiral aptamers into the gold nanoclusters would result in a nice chiral tyrosinamide recognition. This work has a liner range ranging from 1 nM to 10 μM. Furthermore, the ratio of the peak current change was 4. This study might provide a useful strategy for designing sensitive chiral recognition devices with chiral aptamer-modified materials and restricting their electrochemical currents.