Simultaneous determination of environmental endocrine disruptors bisphenol A and 4-nitrophenol bleached from food-contacting materials using the spin-ladder compound La2Cu2O5 modified glassy carbon electrode

Environmental endocrine-disrupting chemicals, Bisphenol A (BPA) and 4-Nitrophenol (4-NP), pose significant risks to reproductive health in both animals and humans. Here, we introduce the first utilization of the 4-leg spin ladder compound La 2 Cu 2 O 5 as an electrode material for electrochemical sensor. Nanostructured La 2 Cu 2 O 5 was synthesized via a straightforward Sol-Gel method and thoroughly characterized using X-ray photoelectron spectroscopy, high-resolution transmission electron microscopy, and powder X-ray diffraction. La 2 Cu 2 O 5 nanoparticles modified glassy carbon electrode (GCE) exhibited a significant electrocatalytic activity towards the oxidation of BPA and 4-NP in phosphate buffer saline (pH 7.0). Square wave voltammetry studies revealed lowest detection limits of 3 nM for BPA and 2.6 nM for 4-NP over a wider concentration range of 0.01–500 μM. Notably, this study marks the first utilization of La 2 Cu 2 O 5 for simultaneous electrochemical detection of BPA and 4-NP, demonstrating its potential in this field. Furthermore, the sensor exhibited good sensitivity, reproducibility, and selectivity towards BPA and 4-NP, even in the presence of similar potential organic and inorganic interferents. Additionally, the newly developed sensor enabled simultaneous quantification of BPA and 4-NP in real samples such as packaged milk, river water, and plastic bottles, achieving recovery rates above 95%. Importantly, our results underscore the leaching of BPA into water from thin and thick plastics at elevated temperatures (40 °C–80 °C), emphasizing the utility of the proposed sensor for rapid and simultaneous detection of BPA and 4-NP in environmental and food matrices.