Preparation of novel dialdehyde bionic antimicrobial peptides and their antimicrobial activities

Cellulose-based antibacterial materials can effectively reduce the use of antibiotics without increasing bacterial resistance. In this study, dialdehyde AMPMs (DAMPMs) were prepared by selective oxidation of C2 and C3 hydroxyl groups on carboxymethyl cellulose bionic antimicrobial peptides using sodium periodate . DAMPMs with different degrees of oxidation were prepared by varying the concentration of the oxidizing agent . As the degree of oxidation increases, the surface of DAMPMs became loose and porous, and the crystallinity and thermal stability decrease. The DAMPMs showed excellent antibacterial activity against E.coli and S.aureus , and the antibacterial activity against S.aureus was better than that against E.coli . Except for D 1 AMPMs, the antibacterial rate of D 2–4 AMPMs were more than 90 %. The bacterial cells treated with DAMPMs became larger, the integrity of the cell structure was destroyed, and the cell contents spilled out. More importantly, DAMPMs showed no cytotoxicity and good biocompatibility at concentrations ranging from 0.5 to 3 mg/mL. DAMPMs are effective bio-antimicrobial materials that provide certain theoretical basis and new ideas for expanding the development and utilization technology of cellulose.