Preparation of magnetic molecular imprinted polymers based on deep eutectic solvent and its application in the specific adsorption and detection of fluoxetine hydrochloride

Magnetic molecular imprinted polymers (MMIPs) for specific adsorption of fluoxetine hydrochloride (FXT) were prepared by using a new solvent, deep eutectic solvents (DESs) as the porogen, magnetic Fe 3 O 4 nanoparticles modified twice as the carrier and methacrylic acid (MAA) as the functional monomer. The effects of DESs type, molar ratio of functional monomer to template molecule and amount of crosslinker on the adsorption properties of MMIPs were investigated. The characterization results showed that the optimized MMIPs is a rough porous material with a particle size between 300 and 500 nm, and the magnetic properties and thermal properties are satisfactory. The adsorption of MMIPs for FXT reached the equilibrium within 30 min. The equilibrium absorption capacity was 38.54 mg·g −1 with an imprinting factor of 1.88. The constructed MMIPs showed good specificity and reusability. A rapid, simple and economical detection method for residual FXT in environmental water samples was established with the recovery rate between 94.4 and 102.2 %, and LOD and LOQ of 4.0 μg·L −1 and 1.2 μg·L −1 , respectively.