Novel pillar[n]arenes magnetic nanoparticles: Preparation and application in quantitative analysis of trace perfluorinated compounds from aqueous samples

ABSTRACT Background Perfluorinated compounds (PFCs) are a class of widely manufactured and used emerging persistent pollutants. The recent discovered new class of macrocycles pillararenes have garnered significant attention for the applications in environmental pollutant adsorption, with abundant π electron cavities, a symmetrical rigid structure, and host-guest recognition capabilities. Results In this work, we designed and synthesized novel cationic pillar[n]arenes magnetic nanoparticles (CWPA5@MNPs), and investigated its adsorption performance and mechanism as a type of new adsorbent for the enrichment of PFCs. The results indicate that CWPA5@MNPs exhibits selectively strong affinity for perfluorooctane sulfonate (PFOS) and long-chain (C 9 -C 14 ) perfluorocarboxylic acids (PFCAs), with the adsorption efficiency exceeding 80% within 12 minutes. The maximum adsorption capacity of CWPA5@MNPs for PFOS was measured to be 29.02 mg/g. CWPA5@MNPs can be rapidly isolated from the solution using external magnets, offering a quick and easy separation. Consequently, this study established a CWPA5@MNPs-assisted magnetic solid-phase extraction (MSPE) coupled with high-performance liquid chromatography-tandem mass spectrometry (CWPA5@MNPs-MSPE-HPLC-MS/MS) method for the rapid detection of trace levels of PFCs in environmental water samples. The analysis of 7 PFCs yielded recovery rates ranging from 86.1% to 107.5%, with intraday and interday relative standard deviations (RSD) of 3.6-6.4% and 1.3-7.0%, respectively. Significance and Novelty The study reveals the synthesis and application of novel cationic pillar[n]arenes magnetic nanoparticles (CWPA5@MNPs) as highly efficient adsorbents for selective perfluorinated compounds (PFCs) in water samples. It demonstrates the potential of the newly developed CWPA5@MNPs-MSPE-HPLC-MS/MS method for the quantitative analysis of PFCs in environment, with high sensitivity, accuracy and stability.