Mn2O@Zn-N nanocarbon based on pyrolytically ZIF-8-on-MnO2 as high-performance electrochemical sensor for ultrasensitive detection of rifampicin in environmental samples

Rifampicin (RFP) is an emerging environmental pollutant that exists in natural waters due to discharged from the medical and pharmaceutical industries, posing potential risks to aquatic life and human health. Developing highly sensitive detection techniques for RFP is essential for environmental monitoring and public health protection. In this work, Mn 2 O@Zn-NC was synthesized using in-situ growth and pyrolysis methods. Rod-like MnO 2 providing dispersed sites for the growth and crystallization of dodecahedral ZIF-8,with dodecahedral ZIF-8 tightly encapsulates MnO 2 . Additionally, the Zn-NC formed after high-temperature treatment effectively addresses the issue of poor conductivity in MnO 2 , which is conducive to the accurate display of RFP current signals. Using material of Mn 2 O@Zn-NC, a high-sensitivity electrochemical sensor was developed with a detection range of 0.040–100 µM and a limit of detection of 25 nM. This highly sensitive sensor can accurately detect RFP in environmental samples, with results comparable to those obtained using UV-Vis spectroscopy. This breakthrough electrochemical detector provides valuable opportunities for creating smart, efficient, and portable monitoring solutions.