High-resolution 3D Radiochromic Hydrogel Photonic Crystal Dosimeter for Clinical Radiotherapy

The precise, rapid and direct visualization of 3D topographical dose in the target tissue that is crucial for effective radiation therapy remains a challenge. Herein, by combining hydrogel photonic crystals with film stacking or 3D printing, a 3D radiochromic dosimeter with a dose sensitivity up to 10 nm/Gy, a spatial resolution < 50 μm, and the ability to detect complex 3D topographical dose distribution was proposed for clinical radiation dose verification. The performance of the dosimeter by radiation-induced polymer cross-linking and consequent Bragg wavelength shift can be tuned via the solid content and extent of acrylate modification. The combination of rapid readout, low dose response, high spatial resolution, and good environmental stability highlights the translational potential of this technology for topographical dose mapping in clinical radiotherapy applications.