Enzyme-catalyzed hydrolysis of surface polycaprolactone for enhanced cell adhesion on polycaprolactone-based composite scaffolds

In this study, a porous polycaprolactone (PCL) −based scaffold was treated with lipase to create a hierarchical pore structure. The lipase treatment increased the surface roughness and hydrophilicity, leading to enhanced cell adhesion compared to the untreated scaffold. The hierarchical pore structure of the lipase-treated scaffold shows promise for bone regeneration. This lipase treatment approach offers a new method for designing tissue engineering scaffolds.