DC-Derived Whole Cell Cytokines Nano-Regulator for Remodeling Extracellular Matrix and Synergizing Tumor Immunotherapy

A smart dendritic cells (DC)-derived whole cell cytokines (DWCs) nano-regulator of TCP was developed for tumor cytokine-immunotherapy. The DWCs were purified from activated DC-cultured mediums and applied as a nano-dosage form. It was found that TCP could remodel extracellular matrix via the elimination of fibronectin and type I collagen (Col-I) in tumor tissues, as well as the inhibition of α-SMA expression in cancer associated fibroblasts (CAF). Furthermore, after local TCP treatment, significant tumor inhibition could be achieved combined with radiotherapy.