Bubble linking anterior growth strategy to prepare hydrogel tubes with different range, branch and voyager function

Hydrogel tubes (HTs) represent a significant facet of hydrogel morphology. Nevertheless, the continuous, rapid, and facile fabrication of hydrogel tubes remains a formidable challenge. In this study, we introduce a novel technique named as Anterior Growth (AG) for the continuous preparation of HTs. This innovative approach employs air bubbles as guidance to direct the growth of polyvinyl alcohol (PVA) HTs crosslinked by copper ions in alkaline solution. Various factors that affect the sizes of HTs from micrometers to millimeters have been explored, including gauge of needles, air bubble volumes, injection rates, and concentrations of NaOH, copper nitrate and PVA. Single HT with various sizes can be easily fabricated by simply adjusting injection rates. The reversibility of PVA-Cu 2+ crosslinking makes it possible to produce HTs with multiple branches in a convenient way by generating an orifice out of the HT wall and then repeating the growing process. Inspired by plant thigmotropism, HTs can be guided to grow along designed shapes such as different angles and patterns by combination of air bubble and silicone rubble substrates. Remarkably, this method allows HTs to serve as voyagers navigating intricate flow channels with a projected trajectory, indicating the capabilities of patterning and traversing complex channels. To further application, AG allows other materials to prepare HTs such as sodium alginate or more, showcasing excellent practical value.