A Hydrogen-Bonded biohybrid organic framework hydrogel for enhanced diabetic wound therapy

Diabetic wound leads to numerous infections or deaths each year due to the prevalence of multidrug-resistant (MDR) bacterial infection. Herein, we constructed a hydrogen-bonded biohybrid organic framework (HOF) hydrogel (GOx@ TH HOF-Ce6(Fe)) by the hierarchical assembly of the rational designed carboxyl terminal ligand BTH and amidinium ligand TAM. The imidazolyl in BTH forms the axial coordination with Ce6(Fe), and the amide bonds in BTH promotes the structural flexibility of HOF. Upon involving glucose oxidase (GOx) and Ce6(Fe), GOx@ TH HOF-Ce6(Fe) hydrogel displayed high peroxidase-like activity, superior stability and biocompatibility, which exhibited better photodynamic therapy (PDT) and chemodynamic therapy (CDT) efficacy for enhanced antimicrobial diabetes wound treatment. This work developed a pioneering photo-assisted biocatalytic cascade strategy within HOF hydrogel, which provides new insights into the design and application of HOF materials in biomedical field.