A portable multi-signal readout sensing platform based on plasmonic MXene induced signal amplification for point of care biomarker detection

Biomarkers detection is of great significance in disease screening, early diagnosis and treatment responses. Herein, a plasmonic MXene induced multi-signal readout sensing platform was proposed for portable and ultrasensitive human anti-asialoglycoprotein receptor (human anti-ASGPR) detection, a biomarker for hepatitis. The plasmonic nanohybrid Ti 3 C 2 [email protected] prepared by decorating Ti 3 C 2 MXene with copper nano-clusters (Cu NCs) presented outstanding photothermal property and catalyst activity, which was developed as a signal reporter and participate in immune recognition event. The Ti 3 C 2 [email protected] induced visual color change from moderate blue to deep blue in the oxide-reduce methylene blue (MB-MBH 2 ) colorimetric system due to Cu NCs catalyzed more methylene blue (MB) produce. And the formation of Ti 3 C 2 [email protected] /MB complex presented brilliant photo-to-thermal conversion ability, under near infrared (NIR) laser radiation, enhanced photothermal effect from Ti 3 C 2 [email protected] /MB complex triggered significantly amplified temperature elevation in a temperature-responsive soft electronic devices (SED). Simultaneously, increased temperature greatly affected the conductivity variation in SED, this can be monitored by a commercially available digital multimeter (DMM) with resistance readout and transferred the laser stimulus into measurable electrical signal. Overall, such a new multi-signal readout biosensor realized sensitive target detection with high precision, low cost and simple operation.