Multienzymatic Antioxidant Activity of Manganese-Based Nanoparticles for Protection against Oxidative Cell Damage

Oxidative stress is related to many diseases, but available clinical treatment methods are currently limited. Exploitation of enzyme-mimicking nanomaterials (nanozymes) is a promising way for scavenging reactive oxygen species (ROS) and treatment of ROS-related diseases. Herein, the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) mimicking activities are expressed by MnO2 nanoparticles (MnO2–BSA NPs) coated with BSA. Effective •OH removal activity is also expressed by MnO2–BSA NPs at neutral pH. Apoptosis inhibition and ROS scavenging capabilities of MnO2–BSA NPs are evident on the H2O2-exposed BEAS-2B cells line. Western blot analysis indicates that MnO2–BSA NPs inhibit H2O2-induced apoptosis by mediating the expression of apoptosis-related proteins.