Dual function metal-organic frameworks based ratiometric electrochemical sensor for detection of doxorubicin

Cancer is one of the main diseases threatening human health in the world. Doxorubicin (DOX) is a common anti-cancer drug that can be used for chemotherapy to extend a cancer patient's life. It is our common wish that treatment process of cancer is efficient and secure. Therefore, it is of great significance to develop sensitive, rapid and accurate techniques for anti-cancer drug doxorubicin (DOX) detection. Herein, in our work, a ratiometric electrochemical sensor for DOX detection was designed, which based on MB@MWCNTs/UiO-66-NH 2 composites. The porous materials UiO-66-NH 2 magically shoulder double function in our ratiometric electrochemical strategy, which can reduce the interior error caused by the various complex materials. Specifically, on the one hand, it can be used to catalyze DOX, which can provide a great current signal to be detected, on the other hand, its special property of absorbing molecules was utilized to load materials as internal reference. Consequently, we chose methylene blue (MB) as the substance that can generate an internal reference signal, because it is a specific and stable electroactive substance. Then, we added MWCNTs as a part of the material modified on the ratiometric electrochemical platform to enhance the signal of the target due to its feature of good electrical conductivity . Under the optimized conditions, the ratiometric electrochemical sensor displayed a wide linear detection with the range from 0.1 μM to 75 μM and the limit of detection (LOD) of 0.051 μM. The applicability of this method in the analysis of actual human saliva samples has been confirmed by the results of selectivity , stability, and reproducibility tests, which was prospective in clinical application.