Versatile Au@Ru nanocomposites for the rapid detection of Salmonella typhimurium and photothermal sterilization

In view of the current public health hazards of food-borne pathogens, it is urgent to develop a rapid detection method with high sensitivity, good specificity and operational convenience, as well as to determine an effective sterilization strategy. Herein, versatile gold-ruthenium nanocomposites modified with antibody ( [email protected] Ncs) have been constructed for the sensitive detection of Salmonella typhimurium (S. typhimurium) via the lateral flow immunochromatographic assay (LFIA). [email protected] Ncs based LFIA exhibited a wide detection range from 2.9 × 10 6 CFU/mL to 2.9 × 10 11 CFU/mL with the limit of detection of 9.8 × 10 4 CFU/mL for S. typhimurium, and displayed excellent specificity. In addition, [email protected] Ncs irradiated with 808 nm (500 mW/cm 2 ) near-infrared light (NIR) had a significant antibacterial effect within only 5 min, attributed to its high photothermal conversion efficiency of 54.14%. Therefore, both sensitive detection of S. typhimurium and effective NIR-triggered photothermal sterilization were achieved by using versatile [email protected] Ncs, showing great prospects in the field of pathogen detection and treatment.