A cascade catalytic system of photocatalytic oxidation based on Cu@PCN-222(Ni) and enzyme catalysis for the synthesis of chalcone compounds in one pot

High-efficiency photo-enzymatic synthesis of chalcone chemicals was achieved by tandem catalysis based on the photocatalytic oxidation of porphyrin-based metal organic frameworks (MOFs) confined copper nanoclusters and the non-specific catalytic activity of hydrolases. A series of photocatalysts were successfully synthesized and the Cu nanoparticles (NPs) were loaded on the materials by in-situ reduction of Cu 2+ . Subsequently, in situ oxidation of benzyl alcohol and aldol reaction catalyzed in tandem by Cu@PCN-222(M) and hydrolase were used as template reactions and the reaction conditions were systematically studied. 20 chalcone derivatives were successfully synthesized (yield up to 98 %). Finally, the optical properties difference of photocatalysts were studied by spectroscopic and electrochemical analysis. The reaction system used greener benzyl alcohol as the reaction substrate and was driven by visible light under O 2 . This method has good yield and recovery performance, which provides a new strategy for the construction of MOF-enzyme combined catalytic system.