Radiation-sensitive nanogel-incorporated Fricke hydrogel dosimeters with reduced diffusion rates

Fricke gel dosimeters have great potential for three-dimensional (3D) dose verification in radiation therapy; however, they suffer from time-dependent ion diffusion after irradiation, severely affecting their stability and reliability. In this work, a pullulan-based amphiphilic molecule was synthesized, characterized, and self-assembled into nanogels. Nanogel structures were embedded into gel dosimeters to reduce the diffusion rates, and radiation-sensitive nanogel-incorporated Fricke hydrogel nanocomposites were prepared successfully. The results demonstrated that the diffusion coefficient of improved dosimeters was reduced to 0.125 ± 0.001 mm 2 h −1 , while maintaining the high optical dose sensitivity (0.0410 ± 0.0004 Gy −1 cm −1 ). It provides a powerful tool toward the practical application of 3D dosimeters.