Bamboo-Inspired Gasotransmitter Microfibres for Wound Healing

Diabetic wounds have become a major clinical problem that cannot be ignored. Gases, such as hydrogen sulphide (H 2 S), have demonstrated value in inducing angiogenesis and accelerating wound healing, while their effective delivery is still challenging. Here, inspired by the continuous-independent hollow structure of bamboo, we propose novel gasotransmitter microfibres with septal H 2 S bubbles using microfluidic spinning for diabetic wound healing. Benefitting from the exact control of microfluidics, gasotransmitter microfibres with different bubble sizes and morphologies could be generated successfully and continuously. Under the dual effects of drugs in the shell and gas in the core, the wound healing process could be accelerated. Furthermore, the controllable release of drugs could be achieved by adding responsive materials into the microfiber shell, which would promote continuous effects of contents on demand. Based on in vitro and in vivo studies, we have proven that these gasotransmitter microfibres have a positive impact on inducing angiogenesis and promoting cell proliferation during wound healing. Thus, it is believed that the bamboo-inspired gasotransmitter microfibres will have important value in gasotransmitter research and clinical applications. Graphical Abstract The bamboo-inspired microfibres are presented through microfluidics with features of independent chambers for storing and controlled release of hydrogen sulphide (H 2 S) to the diabetic wound. Even if it is partially damaged, it will not affect the overall gas storage and utilization. Thus, it contributes to improvements in basic research and the transformation of gasotransmitters.