Near-infrared Light-accelerated Glucose Oxidase-MoS2 Cascade Catalytic Chemodynamic Therapy in Synergistic Cationic Polymer Hydrogels to Combate Multibacterial Infection

Graphical A dopamine-modified oxidized hyaluronic acid was used as the backbone of a hydrogel, which was physically mixed with Fe 3+ , poly(lysine) and glucose oxidase loaded onto PEI-coated MoS 2 nanosheets to construct a multimodal synergistic antibacterial hydrogel. It is combined with the cationic antimicrobial properties of the hydrogel and the photothermal effect of MoS 2 to achieve multimodal synergistic bactericidal action. Given the poor antibacterial activity of hydrogels, a multimodal synergistic antibacterial hydrogel based on dopamine-modified oxidized hyaluronic acid was developed, and its antibacterial activity and biocompatibility were demonstrated. First, dopamine-modified oxidized hyaluronic acid (OHA-DA) was used as the hydrogel backbone. A dual-dynamically cross-linked injectable hydrogel was constructed by mixing OHA-DA, Fe 3+ with cationic antimicrobial peptide polylysine (EPL) via Schiff base and coordination complexation. Next, glucose oxidase-loaded MoS 2 nanosheets were synthesized through electrostatic interaction and loaded into the hydrogel through physical mixing. Finally, a multimodal synergistic antibacterial hydrogel OD/EPL/GM was obtained. Antibacterial experiments show that the hydrogel has good antibacterial activity against E. coli and S. aureus , and the antibacterial rate can reach 99.99%.