A novel approach of modeling pharmacokinetics and pharmacokinetics-pharmacodynamics for the intravenous nano drug delivery system

A clear and systematic understanding of the drug's in vivo performance leading to the bioavailability of the drug substance is of paramount importance in drug design , development, medical applications, and toxicity evaluation. In contrast to the conventional injectable solution dosage forms, the intravenous nano-Drug Delivery Systems (DDS) are divided into two parts: free and encapsulated drugs. The encapsulated drug is the key to improving release and distribution in vivo. However, researching the pharmacokinetics (PK) and pharmacodynamics (PD) of the nano-drug delivery system using the classical compartment models for traditional solution dosage forms is problematic in that the encapsulated and free drugs are co-existent, thus warranting more consideration in the nano-drug delivery system. In this paper, we proposed a novel approach of modeling PK and PK-PD's “linear multiple input and single output system” for intravenous nano-drug delivery system, which can accurately predict the velocity and distribution of free-drug and encapsulated-drug. The new approach will play a great role in facilitating the development of scutellarin emulsion as the model of drug delivery system, providing insight into the clinical translation of nano-medicine, and shedding some light on the future of precision medicine and personalized medicine.