Enhanced Antibacterial And Wound Healing Using A Metal-Organic Cluster Inspired by Artificial Photosynthesis

Bacterial infection poses a constant threat to human health. It is crucial to develop cost-effective and multifunctional solutions to combat bacteria. In this study, we have taken inspiration from artificial photosynthesis and creatively formulated a hydrogel containing a photocatalytic metal-organic cluster (MOC) for wound healing and antibacterial purposes. Complete photocatalytic cycles have been achieved by combining the oxidative Ti-center and the reductive Cu-center, in which reactive oxygen species ( 1 O 2 and ·OH) have been generated. The MOC has the capability to eliminate S. aureus and E. coli at a concentration of 40 μg·mL −1 . In addition, the hydrogel formulation (H-MOC) has been applied to wounds infected with S. aureus , resulting in improved healing efficiency. This work presents an innovative approach to utilizing photocatalytic biomaterials as non-antibiotic medications. This article is protected by copyright. All rights reserved