TiO2-doped bilirubin-imprinted polydopamine cored with Fe3O4 nanoparticle for bilirubin selective adsorptivity enhancement

As one of the essential treatments for bilirubin removal in clinical, hemoperfusion of bio-sorbents required efficacy, efficiency and biosafety. Dopamine of biocompatibility and spontaneous polymerization was herein proposed for the bilirubin-imprinted adsorptive polymers of selectivity, doped with TiO 2 of adsorptivity and Fe 3 O 4 as fixed magnets. Via electrostatic reaction and hydrogen bonding, the magnetic sorbents composed of polydopamine doped with TiO 2 removed bilirubin of 263.5 mg·g −1 non-homogeneously during 240 min. With a competitive adsorption coefficient (t N ) of 10.4, the magnetic sorbents also exhibited the decent blood compatibility of acceptable hemolysis ratio and plasma recalcification time. Prospectively, the TiO 2 -doped bilirubin-imprinted PDA cored with Fe 3 O 4 was potentially for bilirubin selective removal via hemoperfusion in clinic.