Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata

Ampelopsis grossedentatais a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China.A. grossedentatahas numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, two new flavonoids (1–2) and seventeen known compounds (3–19) were isolated and identified from the dried stems and leaves ofA. grossedentata. These isolated compounds were characterized by various spectroscopic data including mass spectrometry and nuclear magnetic resonance spectroscopy. All isolates were assessed for their α-glucosidase inhibitory, antioxidant, and hepatoprotective activities, and their structure–activity relationships were further discussed. The results indicated that compound1exhibited effective inhibitory activity against α-glucosidase, with an IC50value of 0.21 μM. In addition, compounds1–2demonstrated not only potent antioxidant activities but also superior hepatoprotective properties. The findings of this study could serve as a reference for the development ofA. grossedentata-derivedproducts or drugs aimed at realizing their antidiabetic, antioxidant, and hepatoprotective functions.Keywords:Ampelopsis;Ampelopsis grossedentata;flavonoids;α-glucosidase inhibitory;antioxidant;hepatoprotective activity