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Liquiritin - ≥98% (HPLC) ,from Glycyrrhizae root (licorice root), high purity , CAS No.551-15-5

14 Citations COA COA
    Grade & Purity:
  • ≥98%(HPLC)
En stock
Item Number
L101535
Articles du produit groupé
SKU Taille
Disponibilité
 Prix Qté
L101535-10mg
10mg
2
78,90$US
L101535-50mg
50mg
3
246,90$US
L101535-250mg
250mg
3
1 111,90$US
L101535-1g
1g
2
4 001,90$US
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View related series
Glucose Metabolism (1943) Immunology/Inflammation (1929) Metabolic Enzyme/Protease (4860) NF-κB (747) Reactive Oxygen Species (309)

Description générale

Synonymes LIQUIRITIGENIN 4'-beta-D-GLUCOPYRANOSIDE | (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)phenyl]chroman-4-one | CHEBI:80845 | CCG-268869 | (2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymet
Spécifications et pureté ≥98%(HPLC)
Mécanismes biochimiques et physiologiques Liquiritin has been attributed to show antidepressant-like and antioxidant activity. It causes apoptosis in cell lines having gastric cancer and promyelocytic leukemia. Liquiritin also demonstrates neurotrophic effects and hence has been considered as a p
Température de stockage Store at 2-8°C,Argon charged
Expédié en
Wet ice
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Product Description

Product Describtion:

Liquiritin is a type of flavone, present as an active ingredient in Glycyrrhiza uralensis and Glycyrrhiza glabra extract. It is a constituent of many traditional Chinese medicine formulas popularly used as a cure for asthma, peptic ulcers, and cough.

Product Application:

Liquiritin has been used to analyze the extract of Glycyrrhiza uralensis and examine its components for anti-Hepatitis C virus activity.  

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Classe Flavonoids
Subclass Flavonoid glycosides
Intermediate Tree Nodes Not available
Direct Parent Flavonoid O-glycosides
Alternative Parents 7-hydroxyflavonoids  Flavanones  Phenolic glycosides  Hexoses  Chromones  O-glycosyl compounds  Aryl alkyl ketones  Phenoxy compounds  Phenol ethers  1-hydroxy-2-unsubstituted benzenoids  Alkyl aryl ethers  Oxanes  Secondary alcohols  Acetals  Polyols  Oxacyclic compounds  Hydrocarbon derivatives  Primary alcohols  Organic oxides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Flavonoid-4p-o-glycoside - Flavonoid o-glycoside - 7-hydroxyflavonoid - Flavanone - Hydroxyflavonoid - Flavan - Phenolic glycoside - Hexose monosaccharide - Chromone - Glycosyl compound - O-glycosyl compound - Chromane - Benzopyran - 1-benzopyran - Phenoxy compound - Aryl alkyl ketone - Aryl ketone - Phenol ether - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Oxane - Monocyclic benzene moiety - Monosaccharide - Benzenoid - Secondary alcohol - Ketone - Acetal - Organoheterocyclic compound - Oxacycle - Ether - Polyol - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Primary alcohol - Alcohol - Organooxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as flavonoid o-glycosides. These are compounds containing a carbohydrate moiety which is O-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone.
External Descriptors flavanones

Cibles associées (humaines)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
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P4HB Tchem Protein disulfide-isomerase (716 Activities)
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GMNN Tbio Geminin (128009 Activities)
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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
microRNA 21 (64692 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Cibles associées (non humaines)

NA Neuraminidase (1107 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Influenza A virus (11224 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDCK (10148 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Giardia (1682 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mécanismes d'action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name Références

Noms et identifiants

Pubchem Sid 504758955
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504758955
IUPAC Name (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one
INCHI InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
InChIKey DEMKZLAVQYISIA-ZRWXNEIDSA-N
Smiles C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
Isomères SMILES C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
Poids moléculaire 418.39
Reaxy-Rn 25451060
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25451060&ln=

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot Number Certificate Type Date Article
H2304386 Certificate of Analysis May 09, 2025 L101535
H2304394 Certificate of Analysis May 09, 2025 L101535
H2304392 Certificate of Analysis May 09, 2025 L101535
H2304393 Certificate of Analysis May 09, 2025 L101535
H2304390 Certificate of Analysis May 09, 2025 L101535
K2228230 Certificate of Analysis Sep 13, 2024 L101535
K2228228 Certificate of Analysis Sep 13, 2024 L101535
A2208111 Certificate of Analysis Oct 12, 2023 L101535
H2304391 Certificate of Analysis Jul 08, 2023 L101535
D2425045 Certificate of Analysis Jul 08, 2023 L101535
D2514033 Certificate of Analysis Jul 08, 2023 L101535
D2515011 Certificate of Analysis Jul 08, 2023 L101535
G2306146 Certificate of Analysis Aug 23, 2022 L101535
K2228229 Certificate of Analysis Aug 23, 2022 L101535
K2004095 Certificate of Analysis Aug 12, 2022 L101535
G1809149 Certificate of Analysis Feb 23, 2022 L101535
A2208112 Certificate of Analysis Dec 17, 2021 L101535
A2208114 Certificate of Analysis Dec 17, 2021 L101535
A2208083 Certificate of Analysis Dec 17, 2021 L101535

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Propriétés chimiques et physiques

Sensibilité Heat Sensitive
Point de fusion (°C) 207°C
Poids moléculaire 418.400 g/mol
XLogP3 0.400
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 4
Exact Mass 418.126 Da
Monoisotopic Mass 418.126 Da
Topological Polar Surface Area 146.000 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 593.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu.  (2023)  Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.  JOURNAL OF ETHNOPHARMACOLOGY,    (117136). 
2. Yinhuang Gao, Ke Ma, Zhibo Zhu, Yan Zhang, Qiong Zhou, Jing Wang, Xiaowen Guo, Liuting Luo, Haitao Wang, Kang Peng, Menghua Liu.  (2023)  Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways.  PHYTOMEDICINE,  114  (154797). 
3. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen.  (2022)  Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.  BIOMEDICINE & PHARMACOTHERAPY,  154  (113571). 
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074). 
5. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu.  (2021)  Study on the interaction of hyaluronidase with certain flavonoids.  JOURNAL OF MOLECULAR STRUCTURE,  1241  (130686). 
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519). 
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807). 
8. Li Peng, Manman Zhu, Lingyi Zhang, Haiyan Liu, Weibing Zhang.  (2016)  Preparation and evaluation of 3 m open tubular capillary columns with a zwitterionic polymeric porous layer for liquid chromatography.  JOURNAL OF SEPARATION SCIENCE,  39  (19): (3736-3744). 
9. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang.  (2012)  Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms.  PHYTOTHERAPY RESEARCH,  27  (8): (1232-1236). 
10. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263). 
11. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,    (143873). 
12. Jing Xu, Yulong Zhu, Yi Wei, Peirong Gan, Shilin Xia, Ya Li, Xiaoman Jiang, Yan Wang, Hong Wu.  (2025)  Analyzing How Zhizi Baipi Decoction Regulates VEGF to Suppress RA Angiogenesis Using Network Pharmacology and Experimental Validation.  PHYTOCHEMICAL ANALYSIS,     
13. Liang Jiayu, Li Xiaofeng, Chen Jinhong, Deng Fangjun, Fan Boya, Zhen Xin, Cong Zidong, Tao Rui, Yu Lu, Qian Shule, Wang Runying, Du Wuxun.  (2024)  Study on the mechanisms and Pharmacodynamic substances of Lian-Gui-Ning-Xin-Tang on Arrhythmia Therapy based on Pharmacodynamic–Pharmacokinetic associations.  Heliyon,  10   
14. Peng Deng, Qifan Wang, Shengfang Wu, Xiuwen Zhou, Fatih Oz, Qiuming Chen, Zhaojun Wang, Zhiyong He, Jie Chen, Maomao Zeng.  (2025)  Synergistic effect of spice extracts on multiple hazards formation and sensory markers in beef flavoring.  Food Bioscience,  65  (106099). 

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