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liquiritigenin , CAS No.69097-97-8, Agonist of Estrogen receptor-β;Channel blocker of TRPM3

1 Citations COA COA
  • Cas Number:  69097-97-8
  • Molecular Weight:  256.26
  • PubChem CID: 1889
In stock
Item Number
L611542
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L611542-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
L611542-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$4,001.90
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View related series
Estrogen receptor-β Agonist (14) Glucose Metabolism (1943) TRPM3 Channel blocker (10)

Basic Description

Synonyms 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one | NCGC00247525-01 | DL-Liquiritigenin | CS-0145110 | MFCD00287289 | 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)- | SMR000470946 | MLS000697612 | (R/S)-Liquiritigenin | BD
Specifications & Purity Moligand™
Grade Moligand™
Action Type AGONIST, CHANNEL BLOCKER
Mechanism of action Agonist of Estrogen receptor-β;Channel blocker of TRPM3

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Flavonoids
Subclass Flavans
Intermediate Tree Nodes Not available
Direct Parent Flavanones
Alternative Parents 7-hydroxyflavonoids  4'-hydroxyflavonoids  Chromones  Aryl alkyl ketones  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Benzene and substituted derivatives  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents 4'-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Flavanone - Chromone - Chromane - 1-benzopyran - Benzopyran - Aryl alkyl ketone - Aryl ketone - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Monocyclic benzene moiety - Benzenoid - Ketone - Oxacycle - Organoheterocyclic compound - Ether - Organic oxygen compound - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as flavanones. These are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3.
External Descriptors a flavanone

Associated Targets(Human)

ESR2 Tclin Estrogen receptor beta (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Aspergillus niger (16508 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
INCHI InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2
InChIKey FURUXTVZLHCCNA-UHFFFAOYSA-N
Smiles C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
Isomeric SMILES C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
PubChem CID 1889
Molecular Weight 256.26

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 256.250 g/mol
XLogP3 2.200
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 1
Exact Mass 256.074 Da
Monoisotopic Mass 256.074 Da
Topological Polar Surface Area 66.800 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 335.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Siyu Yuan, Jun Guo, Bijun Yang, Aolin Xiao Huang, Shuqi Hu, Yingcan Li, Jingxuan Chen, Bin Yuan, Jing Yang.  (2025)  Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,    (151642). 

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