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Ligustrazine Hydrochloride - 10mM in DMSO, high purity , CAS No.76494-51-4

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Ligustrazine Hydrochloride - 10mM in DMSO, high purity , CAS No.76494-51-4

2 Citations

COA

Grade & Purity:

10mM in DMSO

Cas Number: 76494-51-4
Molecular Weight: 172.66
PubChem CID: 156709

In stock

Item Number

L425881

Grouped product items
SKU	Size	Availability	Price	Qty
L425881-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90

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Compound libraries (12325)

Basic Description

Synonyms	Ligustrazine hydrochloride \| 76494-51-4 \| Ligustrazine HCl \| 2,3,5,6-tetramethylpyrazine hydrochloride \| 2,3,5,6-tetramethylpyrazine;hydrochloride \| tetramethylpyrazine hydrochloride \| 126400-81-5 \| chuanxiongzine hydrochloride \| 7YYD00RL0S \| Ligustrazine (hydrochloride) \| L
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrazines
Intermediate Tree Nodes	Not available
Direct Parent	Pyrazines
Alternative Parents	Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Pyrazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2,3,5,6-tetramethylpyrazine;hydrochloride
INCHI	InChI=1S/C8H12N2.ClH/c1-5-6(2)10-8(4)7(3)9-5;/h1-4H3;1H
InChIKey	RQKFOGXUTRDQPB-UHFFFAOYSA-N
Smiles	CC1=C(N=C(C(=N1)C)C)C.Cl
Isomeric SMILES	CC1=C(N=C(C(=N1)C)C)C.Cl
Molecular Weight	172.66
Reaxy-Rn	11152367
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11152367&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	Hygroscopic
Molecular Weight	172.650 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	172.077 Da
Monoisotopic Mass	172.077 Da
Topological Polar Surface Area	25.800 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	87.800
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jian-Li Qiu, Guo-Feng Zhang, Yu-Na Chai, Xiao-Yan Han, Hai-Tao Zheng, Xiang-Feng Li, Fei Duan, Ling-Yan Chen. (2022) Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor-β/Smad Signaling in an Animal Model of Biliary Atresia. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 381 (3): (257-265).
2. Lu Jianrao, Yi Yang, Pan Ronghua, Zhang Chuanfu, Han Haiyan, Chen Jie, Liu Wenrui. (2018) Berberine protects HK-2 cells from hypoxia/reoxygenation induced apoptosis via inhibiting SPHK1 expression. Journal of Natural Medicines, 72 (2): (390-398).

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