This is a demo store. No orders will be fulfilled.

Orilanolimab (anti-FcRn (FCGRT&B2M)) - Primary antibody, specific to FCGRT & B2M, Human IgG4SP

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182845
Grouped product items
SKU Size
Availability
Price Qty
Ab182845-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab182845-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$359.90
Ab182845-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$889.90
Ab182845-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,429.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Orilanolimab (anti-FcRn (FCGRT&B2M)) - Primary antibody, specific to FCGRT & B2M, Human IgG4SP
Synonyms Alpha chain antibody | Fc fragment of IgG, receptor transporter, alpha antibody | FCGRN_HUMAN antibody | FCGRT antibody | FcRn alpha chain antibody | FcRn antibody | FCRN, alpha chain antibody | IgG Fc fragment receptor transporter alpha chain antibody |
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity FCGRT & B2M
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Orilanolimab (anti-FcRn (FCGRT & B2M)) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab (anti-FcRn (FCGRT & B2M)) blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab (anti-FcRn (FCGRT & B2M)) impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab (anti-FcRn (FCGRT & B2M)) disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 144.6 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

FCGRT Tclin IgG receptor FcRn large subunit p51 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
B2M Tbio Beta-2-microglobulin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling FcRn (FCGRT&B2M) (red) with Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - ELISA
Immobilized Human FcRn/FCGRT&B2M Heterodimer protein, His and Avi tag at 2.0 μg/mL can bind Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) with the EC50 of 15.67 ng/mL.

Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) - SEC
The purity of Orilanolimab (anti-FcRn (FCGRT&B2M)) (Ab182845) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.