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Lidocaine hydrochloride - 10mM in DMSO, high purity , CAS No.73-78-9
Cas Number: 73-78-9
Molecular Weight: 270.8
PubChem CID:
6314
Voltage gated sodium channel blocker
Basic Description
Synonyms
Lidocaine hydrochloride | 73-78-9 | LIDOCAINE HCL | Xyloneural | Lidothesin | Lignocaine hydrochloride | Xylocaine Viscous | Laryng-O-jet | Xilina hydrochloride | Anestacon | Rucaina hydrochloride | Xycaine hydrochloride | Xylotox hydrochloride | Duncaine hydrochloride | Isicaine hy
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Voltage gated sodium channel blocker (IC 50 values are 42 and 210 μM for TTX-sensitive and TTX-resistant DRG channels respectively). Reduces proinflammatory cytokine production and shows anesthetic effects in vivo.
Storage Temp
Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Subclass
Amino acids, peptides, and analogues
Intermediate Tree Nodes
Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent
Alpha amino acid amides
Alternative Parents
Anilides m-Xylenes N-arylamides Trialkylamines Secondary carboxylic acid amides Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework
Aromatic homomonocyclic compounds
Substituents
Alpha-amino acid amide - Anilide - N-arylamide - Xylene - M-xylene - Monocyclic benzene moiety - Benzenoid - Carboxamide group - Secondary carboxylic acid amide - Tertiary amine - Tertiary aliphatic amine - Amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organic oxygen compound - Aromatic homomonocyclic compound
Description
This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
External Descriptors
hydrochloride
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
INCHI
InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
InChIKey
IYBQHJMYDGVZRY-UHFFFAOYSA-N
Smiles
CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
Isomeric SMILES
CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
Molecular Weight
270.8
Reaxy-Rn
3917968
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3917968&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
270.800 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
5
Exact Mass
270.15 Da
Monoisotopic Mass
270.15 Da
Topological Polar Surface Area
32.299 Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
228.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
Citations of This Product
1.
Quanpeng Li, Xueqing Yu, Xiaoyan Zheng, Jing Yang, Junfeng Hui, Daidi Fan.
(2024)
Rapid dissolution microneedle based on polyvinyl alcohol/chitosan for local oral anesthesia. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,
257
(128629).
2.
Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.
(2023)
Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY,
95
(33):
(12470–12477).
3.
Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng.
(2023)
Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice. Advanced Science,
(2302586).
4.
Yang Yang, Sun Jiaxiao, Peng Fei, Liu Haibei, Zhao Guoyan, Chen Junjie, Zhang Wensheng, Qiu Feng.
(2022)
Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide. Frontiers in Pharmacology,
13
5.
Baolin Wang, Xing Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang.
(2019)
Engineering On-Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro-Scale Printing. ADVANCED ENGINEERING MATERIALS,
21
(10):
(1900699).
6.
Mao Yanan, Zhang Xiufeng, Sun Yanfang, Shen Zhong, Zhong Chao, Nie Lei, Shavandi Amin, Yunusov Khaydar E., Jiang Guohua.
(2024)
Fabrication of lidocaine-loaded polymer dissolving microneedles for rapid and prolonged local anesthesia. BIOMEDICAL MICRODEVICES,
26
(1):
(1-12).
7.
Xiu-Ying He, Yui-Si Yang, Yue-Xiang Zheng, Qing-Jie Xia, Hong-Zhou Yu, Xiao-Ming Zhao, Ting-Hua Wang.
(2025)
Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling. PLoS One,
20
(1):
(e0318031).
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7 Citations