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| SKU | Size | Availability |
Price | Qty |
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L408441-1ml
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1ml |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$70.90
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Histamine Receptor Agonists
| Synonyms | Alphacaine | 2-(diethylamino)-N-(2,6-dimethylphenyl)-acetamide |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | BLOCKER, CHANNEL BLOCKER |
| Mechanism of action | Sodium channel alpha subunit blocker |
| Product Description |
Information Lidocaine Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. In vivo
cell lines: Concentrations: Incubation Time: Powder Purity:≥99% |
| ALogP | 2.626 |
|---|---|
| hba_count | 1 |
| HBD Count | 1 |
| Rotatable Bond | 5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Smiles | CCN(CC)CC(=O)NC1=C(C)C=CC=C1C |
|---|---|
| Molecular Weight | 234.34 |
| Reaxy-Rn | 2215784 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215784&ln= |
| DMSO(mg / mL) Max Solubility | 47 |
|---|---|
| DMSO(mM) Max Solubility | 200.56 |
| Water(mg / mL) Max Solubility | 9 |
| Water(mM) Max Solubility | 38.41 |
| 1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). |
| 2. Meichao Liao, Lin Yang, Xiaoyue Yang, Erxu Wang, Bin Lu, Jiye Wang, Li Duan. (2023) Vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvent for the urinary excretion study of Taraxacum mongolicum extract in rats. MICROCHEMICAL JOURNAL, 184 (108167). |
| 3. Xiangtian Ling, Xinqi Ma, Xielan Kuang, Yuxiu Zou, Han Zhang, Han Tang, Han Du, Binbin Zhu, Hao Huang, Qing Xia, Minghao Chen, Danyi Mao, Dongli Chen, Huangxuan Shen, Jianhua Yan. (2022) Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway. Drug Design Development and Therapy, |
| 4. Ronghao Liu, Jinjie Hao, Yangyang Wang, Yuanyuan Meng, Yanzhao Yang. (2022) A separation strategy of Au(III), Pd(II) and Pt(IV) based on hydrophobic deep eutectic solvent from hydrochloric acid media. JOURNAL OF MOLECULAR LIQUIDS, 365 (120200). |
| 5. Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang, Li Duan. (2022) A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent. MICROCHEMICAL JOURNAL, 178 (107372). |
| 6. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng. (2022) The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 642 (128609). |
| 7. Boyou Zhang, Fei Sun, Yi Lu, Zhihao Wang, Zhiming Shen, Lei Yuan, Qiang Wu, Cong Wu, Hongcan Shi. (2022) A novel decellularized trachea preparation method for the rapid construction of a functional tissue engineered trachea to repair tracheal defects. Journal of Materials Chemistry B, 10 (25): (4810-4822). |
| 8. Renchuan Liang, Jinghang Jiang, Yanyan Zheng, Ajabkhan Sailjoi, Jie Chen, Jiyang Liu, Hongxue Li. (2021) Vertically oriented mesoporous silica film modified fluorine-doped tin oxide electrode for enhanced electrochemiluminescence detection of lidocaine in serum. RSC Advances, 11 (55): (34669-34675). |
| 9. Jing Li, Yanjun Jiao, Qin Luo, Weixin Hu, Shenwen Fang, Chunling Tang, Qiang Liu. (2021) Treatment of oil-based drill cuttings by hydrophobic deep eutectic solvents. CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 100 (8): (1747-1754). |
| 10. Jing Lu, Wenjie Tian, Linxian Cui, Bing Cai, Tingting Zhang, Nan Huang, Lei Lu, Tao Zhu. (2021) Lidocaine-eluting endotracheal tube effectively attenuates intubation related airway response. Annals of Translational Medicine, 9 (10): (871). |
| 11. Yongqiang Zhang, Yingying Cao, Xiangzhan Meng, Chunshan Li, Hui Wang, Suojiang Zhang. (2020) Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen. COLLOIDS AND SURFACES B-BIOINTERFACES, 189 (110886). |
| 12. Xue Ren, Man He, Beibei Chen, Bin Hu. (2020) Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV. Analytical Methods, 12 (2): (141-148). |
| 13. Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu. (2016) Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection. JOURNAL OF CHROMATOGRAPHY A, 1443 (1). |