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Licarin B - 99%, high purity , CAS No.51020-87-2

Grade & Purity:

≥99%

Cas Number: 51020-87-2
Molecular Weight: 324.4
PubChem CID: 6441061

In stock

Item Number

L651454

Grouped product items
SKU	Size	Availability	Price
L651454-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
L651454-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
L651454-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90

Phenylpropanoids Simple Phenylpropanols

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) GLUT (19) Lipid metabolism (1912) Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) Phenylpropanoids Simple Phenylpropanols (3) PPAR (155) Vitamin D Related/Nuclear Receptor (907)

Synonyms	BDBM50303148 \| Q-100947 \| 5-((2R,3R)-7-methoxy-3-methyl-5-((E)-prop-1-en-1-yl)-2,3-dihydrobenzofuran-2-yl)benzo[d][1,3]dioxole \| AKOS030632872 \| NSC 370990 \| HY-N0479 \| licarine B \| SCHEMBL12604783 \| (+)-licarin B \| DTXSID601317642 \| AC-34420 \| licarinB \|
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans , improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway.
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans , improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway In Vitro Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability AssayCell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. Form:Solid IC50& Target:PPARγ GLUT4

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	2-arylbenzofuran flavonoids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	2-arylbenzofuran flavonoids
Alternative Parents	Lignans, neolignans and related compounds Coumarans Benzofurans Benzodioxoles Styrenes Anisoles Alkyl aryl ethers Oxacyclic compounds Acetals Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	2-arylbenzofuran flavonoid - Neolignan skeleton - Coumaran - Benzodioxole - Benzofuran - Anisole - Styrene - Alkyl aryl ether - Benzenoid - Acetal - Oxacycle - Organoheterocyclic compound - Ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	5-[(2R,3R)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole
INCHI	InChI=1S/C20H20O4/c1-4-5-13-8-15-12(2)19(24-20(15)18(9-13)21-3)14-6-7-16-17(10-14)23-11-22-16/h4-10,12,19H,11H2,1-3H3/b5-4+/t12-,19-/m1/s1
InChIKey	DMMQXURQRMNSBM-YZAYTREXSA-N
Smiles	CC=CC1=CC2=C(C(=C1)OC)OC(C2C)C3=CC4=C(C=C3)OCO4
Isomeric SMILES	C/C=C/C1=CC2=C(C(=C1)OC)O[C@H]([C@@H]2C)C3=CC4=C(C=C3)OCO4
Alternate CAS	51020-87-2
PubChem CID	6441061
MeSH Entry Terms	licarin B
Molecular Weight	324.4

Solubility	DMSO : 100 mg/mL (308.29 mM; Need ultrasonic)
Molecular Weight	324.400 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	324.136 Da
Monoisotopic Mass	324.136 Da
Topological Polar Surface Area	36.900 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	465.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Licarin B - 99%, high purity , CAS No.51020-87-2

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