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Levobupivacaine hydrochloride - 98%, high purity , Sodium channel protein type IV alpha subunit blocker, CAS No.27262-48-2, Sodium channel protein type IV alpha subunit blocker

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 27262-48-2
Molecular Weight: 324.89
EC Number: 642-955-1,690-037-4
PubChem CID: 117965
PubChem SID: 504756774

In stock

Item Number

L276455

Grouped product items
SKU	Size	Availability	Price
L276455-1g	1g	3	$20.90
L276455-5g	5g	3	$68.90
L276455-25g	25g	3	$215.90
L276455-100g	100g	2	$640.90

Long-acting local anesthetic

View related series

Apoptosis (4276) Ferroptosis (356) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Sodium Channel (211)

Basic Description

Synonyms	27262-48-2 (HCl) \| LEVOBUPIVACAINE HCL [VANDF] \| Q27114682 \| 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, (2S)- \| (+/-)-.BETA.-PINENE \| LEVOBUPIVACAINE HYDROCHLORIDE [ORANGE BOOK] \| LEVOBUPIVACAINE HYDROCHLORIDE [WHO-DD] \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	(S)-enantiomer of bupivacaine . Reversible sodium channel inhibitor. Acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Efficacy is similar to that of bupivacaine with a reduce
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	BLOCKER
Mechanism of action	Sodium channel protein type IV alpha subunit blocker
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Piperidinecarboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Piperidinecarboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Piperidinecarboxamides
Alternative Parents	m-Xylenes Trialkylamines Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-piperidinecarboxamide - Piperidinecarboxamide - M-xylene - Xylene - Monocyclic benzene moiety - Benzenoid - Tertiary aliphatic amine - Tertiary amine - Carboximidic acid - Carboximidic acid derivative - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Amine - Hydrochloride - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as piperidinecarboxamides. These are compounds containing a piperidine ring substituted with a carboxamide functional group.
External Descriptors	1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504756774
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504756774
IUPAC Name	(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H/t16-;/m0./s1
InChIKey	SIEYLFHKZGLBNX-NTISSMGPSA-N
Smiles	CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Isomeric SMILES	CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.Cl
Alternate CAS	27262-48-2
MeSH Entry Terms	Chirocaine;levobupivacaine;levobupivacaine hydrochloride
Molecular Weight	324.89
Reaxy-Rn	4048737
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4048737&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
F2229407	Certificate of Analysis	Jul 10, 2025	L276455
F2229408	Certificate of Analysis	Jul 10, 2025	L276455
F2229409	Certificate of Analysis	Jul 10, 2025	L276455
F2229406	Certificate of Analysis	Jul 10, 2025	L276455

Chemical and Physical Properties

Solubility	DMSO (Slightly), Methanol (Slightly)
Molecular Weight	324.900 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	324.197 Da
Monoisotopic Mass	324.197 Da
Topological Polar Surface Area	32.299 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	321.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Qiao Bin, Song Xinye, Zhang Weiyi, Xu Ming, Zhuang Bowen, Li Wei, Guo Huanling, Wu Wenxin, Huang Guangliang, Zhang Minru, Xie Xiaoyan, Zhang Nan, Luan Yong, Zhang Chunyang. (2022) Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-17).

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