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Leukotriene C4 - Moligand™, ≥95%, A solution in ethanol, high purity , CAS No.72025-60-6

COA

Grade & Purity:

Moligand™

≥95%
A solution in ethanol

Cas Number: 72025-60-6
Molecular Weight: 625.77
PubChem CID: 5280493

In stock

Item Number

L1373078

Grouped product items
SKU	Size	Availability	Price	Qty
L1373078-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,077.90
L1373078-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,782.90

Potent leukotriene C 4 receptor agonist

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Metabolite (5307)

Basic Description

Specifications & Purity	Moligand™, ≥95%, A solution in ethanol
Biochemical and Physiological Mechanisms	Potent leukotriene C 4 receptor agonist (EC 50 = 300 nM). Lipid derivative of arachidonic acid and smooth muscle contractant (EC 50 = 11 nM). Causes coronary and renal vasoconstriction in vivo .
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -80°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Peptides
        Level6 Oligopeptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Peptides
Direct Parent	Oligopeptides
Alternative Parents	Gamma-glutamyl peptides Leukotrienes Hydroxyeicosatetraenoic acids Glutamine and derivatives N-acyl-alpha amino acids Alpha amino acid amides Cysteine and derivatives L-alpha-amino acids Tricarboxylic acids and derivatives Thia fatty acids Hydroxy fatty acids N-acyl amines Secondary carboxylic acid amides Secondary alcohols Amino acids Sulfenyl compounds Carboxylic acids Dialkylthioethers Organic oxides Organopnictogen compounds Carbonyl compounds Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Alpha-oligopeptide - Gamma-glutamyl alpha peptide - Leukotriene - Hydroxyeicosatetraenoic acid - Eicosanoid - Glutamine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Cysteine or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - L-alpha-amino acid - Alpha-amino acid - N-substituted-alpha-amino acid - Tricarboxylic acid or derivatives - Hydroxy fatty acid - Thia fatty acid - Fatty amide - N-acyl-amine - Fatty acyl - Secondary alcohol - Amino acid - Carboxamide group - Secondary carboxylic acid amide - Amino acid or derivatives - Dialkylthioether - Carboxylic acid - Sulfenyl compound - Thioether - Primary amine - Organic oxygen compound - Organic nitrogen compound - Alcohol - Carbonyl group - Hydrocarbon derivative - Amine - Organic oxide - Organopnictogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors	Leukotrienes
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
INCHI	InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
InChIKey	GWNVDXQDILPJIG-NXOLIXFESA-N
Smiles	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
Isomeric SMILES	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
Molecular Weight	625.77
Reaxy-Rn	36149246
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36149246&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Supplied in methanol/ammonium acetate buffer, 65:35, pH5.6 (50 µg/ml)
Sensitivity	Light sensitive
Molecular Weight	625.800 g/mol
XLogP3	0.700
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	25
Exact Mass	625.303 Da
Monoisotopic Mass	625.303 Da
Topological Polar Surface Area	242.000 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	982.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	4
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	4
Covalently-Bonded Unit Count	1

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