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Leu-AMS - 98%, high purity , CAS No.288591-93-5

COA

Grade & Purity:

≥98%

Cas Number: 288591-93-5
Molecular Weight: 459.48

In stock

Item Number

L649698

Grouped product items
SKU	Size	Availability	Price
L649698-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$228.90
L649698-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$708.90
L649698-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,068.90

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Aminoacyl-tRNA Synthetase (14) Bacterial (3013) Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase ( LRS ) with an IC 50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase ( LRS ) with an IC 50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria In Vitro Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC 50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 22.34 nM (LRS)

Names and Identifiers

Smiles	O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)CC(C)C)=O)=O
Molecular Weight	459.48

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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