Skip to the beginning of the images gallery

Lerisetron - 98%, high purity , CAS No.143257-98-1

COA

Grade & Purity:

≥98%

Cas Number: 143257-98-1
Molecular Weight: 292.38
PubChem CID: 65997
PubChem SID: 504754016

In stock

Item Number

L412789

Grouped product items
SKU	Size	Availability	Price
L412789-5mg	5mg	3	$480.90
L412789-10mg	10mg	3	$686.90
L412789-25mg	25mg	2	$1,201.90
L412789-50mg	50mg	2	$1,922.90
L412789-100mg	100mg	2	$3,055.90

5-HT3 Selective Inhibitors | Agonists | Antagonists | Modulators

View related series

5-HT Receptor (264) Class A GPCR (4138) GPCR/G Protein (3172) Neuronal Signaling (3320)

Basic Description

Synonyms	PWWDCRQZITYKDV-UHFFFAOYSA-N \| Lerisetron [INN] \| Q6528811 \| 1-benzyl-2-piperazin-1-ylbenzimidazole. \| BCP33052 \| s2644 \| UNII-Q36R82SXRG \| Z2049693817 \| 1-benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole \| EX-A7543 \| L-175 \| 1-Benzyl-2-(1-piperazinyl)benzimi
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Lerisetron (F 0930, F 0930RS) is a5-HT3 receptorantagonist with IC50 of 0.81μM. Targets 5-HT3 receptor (Cell-free assay) 0.81 μM

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	N-arylpiperazines
Alternative Parents	Benzimidazoles Dialkylarylamines N-substituted imidazoles Benzene and substituted derivatives Aminoimidazoles Heteroaromatic compounds Dialkylamines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-arylpiperazine - Benzimidazole - Dialkylarylamine - Aminoimidazole - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Imidazole - Azole - Heteroaromatic compound - Secondary amine - Secondary aliphatic amine - Azacycle - Organopnictogen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.26
hba_count	1
HBD Count	1
Rotatable Bond	3

Associated Targets(Human)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (1 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

Discover Target: HTR2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)

Discover Target: HTR3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)

Discover Target: HTR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Htr3a Serotonin 3 (5-HT3) receptor (1834 Activities)

Discover Target: Htr3a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504754016
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504754016
IUPAC Name	1-benzyl-2-piperazin-1-ylbenzimidazole
INCHI	InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2
InChIKey	PWWDCRQZITYKDV-UHFFFAOYSA-N
Smiles	C1CN(CCN1)C2=NC3=CC=CC=C3N2CC4=CC=CC=C4
Isomeric SMILES	C1CN(CCN1)C2=NC3=CC=CC=C3N2CC4=CC=CC=C4
Molecular Weight	292.38
Reaxy-Rn	7651816
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7651816&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
I2221425	Certificate of Analysis	Jul 12, 2024	L412789
I2221415	Certificate of Analysis	Jul 12, 2024	L412789
I2221418	Certificate of Analysis	Jul 12, 2024	L412789
I2221416	Certificate of Analysis	Jul 12, 2024	L412789
I2221417	Certificate of Analysis	Jul 12, 2024	L412789

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 58 mg/mL (198.37 mM); Ethanol: 58 mg/mL (198.37 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	58
DMSO(mM) Max Solubility	198.371981667693
Water(mg / mL) Max Solubility	＜1
Molecular Weight	292.400 g/mol
XLogP3	2.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	292.169 Da
Monoisotopic Mass	292.169 Da
Topological Polar Surface Area	33.100 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	349.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration