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LDHA-IN-3 - 10mM in DMSO, high purity , CAS No.227010-33-5(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 227010-33-5(DMSO)
Molecular Weight: 301.17

In stock

Item Number

L656553

Grouped product items
SKU	Size	Availability	Price	Qty
L656553-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$165.90

View related series

Compound libraries (12325) Lactate Dehydrogenase (31) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase ( LDHA ) inhibitor ( IC 50 =145.2 nM). LDHA-IN-3 can be used for the research of cancer.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase ( LDHA ) inhibitor ( IC 50 =145.2 nM). LDHA-IN-3 can be used for the research of cancer In Vitro PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells Concentration: 0~500 μM Incubation Time: 48 hours Result: Showed cytotoxic effect. IC50& Target:IC50: 145.2 nM (LDHA)

Names and Identifiers

Smiles	FC(C1=CC=C([Se]C2=CC=CC=C2)C=C1)(F)F
Molecular Weight	301.17

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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