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L-threo-dihydrosphingosine (d18:0) - 98%, high purity , CAS No.15639-50-6

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L-threo-dihydrosphingosine (d18:0) - 98%, high purity , CAS No.15639-50-6

COA

Grade & Purity:

≥98%

Cas Number: 15639-50-6
Molecular Weight: 301.51
MDL number: MFCD00792847
PubChem CID: 3058739

In stock

Item Number

L130602

Grouped product items
SKU	Size	Availability	Price
L130602-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$268.90
L130602-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,001.90
L130602-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,732.90

Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor

View related series

Epigenetics (1496) Histone Modification (1379) PKC (132) Sphingolipids (98) TGF-beta/Smad (303)

Basic Description

Synonyms	L-threo-Dihydrosphingosine \| SMP2_000060 \| 1, 2-amino- (2S,3S) \| 2S,3S-Dihydrosphingosine \| SAFINGOL [USAN] \| SPC-100270 \| Tox21_111227 \| 2S-aminooctadecane-1,3R-diol \| OWA98U788S \| SL-205 \| DB11924 \| NCGC00093867-01 \| Tox21_111227_1 \| Bio1_000520 \| rel-(
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC 50 = 40 µM). Anticancer agent. Potentiates effect of D oxorubicin (DOX) in tumor-bearing animals and cytotoxicity of Mitomycin C in cancer cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A dual inhibitor of PKC and SPHK Application: L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass Amines
      - Level5 Alkanolamines
        Level6 1,2-aminoalcohols

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	Amines
Intermediate Tree Nodes	Alkanolamines
Direct Parent	1,2-aminoalcohols
Alternative Parents	Secondary alcohols Primary alcohols Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Secondary alcohol - 1,2-aminoalcohol - Organic oxygen compound - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Primary aliphatic amine - Alcohol - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
External Descriptors	Sphingoid base analogs
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

Discover Target: MTOR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SPHK1 Tchem Sphingosine kinase 1 (1990 Activities)

Discover Target: SPHK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S,3S)-2-aminooctadecane-1,3-diol
INCHI	InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1
InChIKey	OTKJDMGTUTTYMP-ROUUACIJSA-N
Smiles	CCCCCCCCCCCCCCCC(C(CO)N)O
Isomeric SMILES	CCCCCCCCCCCCCCC[C@@H]([C@H](CO)N)O
WGK Germany	3
Molecular Weight	301.51
Reaxy-Rn	1772584
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1772584&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Soluble in chloroform, water (partly miscible), DMSO (~2 mg/ml), DMF (~10 mg/ml), ethanol, and methanol.
Flash Point(°F)	>230 °F
Flash Point(°C)	>110 °C
Boil Point(°C)	>300° C
Melt Point(°C)	106.8-108.7° C
Molecular Weight	301.500 g/mol
XLogP3	5.800
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	16
Exact Mass	301.298 Da
Monoisotopic Mass	301.298 Da
Topological Polar Surface Area	66.500 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	200.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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